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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
other: published data
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Justification for type of information:
C12 LAS; Linear Alkylbenzene Sulfonate (LAS)) is a very close analogue of Calcium dodecylbenzenesulfonate (CAS No 26264-06-2, EC Number; 247-557-8) ) and read-across is valid.

Data source

Reference
Reference Type:
publication
Title:
Some toxicological properties of surface active agents.
Author:
Hopper, S.S., Hulpieu, H.R. and Cole, V.V.
Year:
1949
Bibliographic source:
J. Am. Pharmacol. Assoc. 38:428-432.

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Mice in groups of 10 were given intravenous injections of C10 or C12 LAS.
GLP compliance:
not specified
Limit test:
no

Test material

Constituent 1
Reference substance name:
C12 LAS
IUPAC Name:
C12 LAS
Test material form:
solid: compact
Details on test material:
- Name of test material (as cited in study report):C12 LAS homologue; C10 LAS homologue

Test animals

Species:
mouse
Strain:
other: albino, Harlan strain
Sex:
not specified

Administration / exposure

Route of administration:
intravenous
Vehicle:
not specified
Doses:
105 mg, 115 mg
Control animals:
yes
Details on study design:
The toxicological properties of several surface-active agents have been investigated. It has been demonstrated that acute toxicity by vein and by mouth are unrelated. Neither are acute and subacute oral toxicity related quantitatively. Blood pressure effects have not been found to be important factors in intravenous toxicity.

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
LD50
Effect level:
105 mg/kg bw
Based on:
test mat.
Remarks:
C12 LAS
Sex:
not specified
Dose descriptor:
LD50
Effect level:
115 mg/kg bw
Based on:
test mat.
Remarks:
C10 LAS

Applicant's summary and conclusion

Conclusions:
The LD50 value of 105 mg/kg (C12 LAS) and 115 mg/kg (C10 LAS) was determined in this study by intravenous route of administration.
Executive summary:

The LD50 value of 105 mg/kg (C12 LAS) and 115 mg/kg (C10 LAS) wasdetermined in this study by intravenous route of administration.The toxicological properties of several surface-active agents have been investigated. It has been demonstrated that acute toxicity by vein and by mouth are unrelated. Neither are acute and subacute oral toxicity related quantitatively. Blood pressure effects have not been found to be important factors in intravenous toxicity.

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