Registration Dossier
Registration Dossier
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EC number: 247-557-8 | CAS number: 26264-06-2
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 972
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Method: other:Test material was applied to shaved area of back of 6 rabbits at two doses: 2000 mg/kg (undiluted) and 212 mg/kg (2% aqueous dilution). The areas were covered with plastic and left in contact with test material for 24 hours.
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Benzenesulfonic acid, C10-16-alkyl derivs.
- EC Number:
- 271-528-9
- EC Name:
- Benzenesulfonic acid, C10-16-alkyl derivs.
- Cas Number:
- 68584-22-5
- IUPAC Name:
- 4-dodecylbenzenesulfonic acid
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report):Benzene sulfonic acid, C10-16-alkyl derivatives (68584-22-5)
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- Test material was applied to shaved area of back of 6 rabbits at two doses: 2000 mg/kg (undiluted) and 212 mg/kg (2% aqueous dilution). The areas were covered with plastic and left in contact with test material for 24 hours.
- Duration of exposure:
- 24 hr
- Doses:
- 2000 mg/kg (undiluted) and 212 mg/kg bw (2% aqueous dilution)
- No. of animals per sex per dose:
- 6
- Control animals:
- not specified
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks:
- undiluted
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 212 mg/kg bw
- Based on:
- test mat.
- Remarks:
- (2% aqueous dilution)
- Mortality:
- All of the animals exposed to the 212 mg/kg survived.
Mortality occurred in three out of six rabbits exposed to the undiluted dose.
LD50 = 2000 mg/kg bw (undiluted); LD50 > 212 mg/kg bw (2% aqueous dilution) - Clinical signs:
- other: Local skin reactions included erythema, mild edema and mild desquamation at 212 mg/kg and chemical burns, severe edema and necrosis at 2000 mg/kg. No untoward behavioral reactions were observed.
- Gross pathology:
- Necropsy did not reveal any gross pathological alterations.
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The acute lethal dermal dose was found to be 2000 mg/kg (undiluted) and LD50 > 212 mg/kg bw (2% aqueous dilution)
- Executive summary:
The acute lethal dermal dose was found to be 2000 mg/kg (undiluted) and LD50 > 212 mg/kg bw (2% aqueous dilution)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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