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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
MSDS Rhodacal CA/70
Author:
Rhodia
Year:
1998
Bibliographic source:
Product Safety labs

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Defined oral LD50. Adapted from appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics, by the Association of Food and Drug Officials of the United States, 1965.
GLP compliance:
no
Test type:
acute toxic class method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Calcium dodecylbenzenesulphonate
EC Number:
247-557-8
EC Name:
Calcium dodecylbenzenesulphonate
Cas Number:
26264-06-2
Molecular formula:
C36H58CaO6S2
IUPAC Name:
calcium dodecylbenzenesulphonate
Test material form:
solid: compact
Details on test material:
- Name of test material (as cited in study report):Benzenesulfonic acid, dodecyl-, calcium salt
Benzenesulfonic acid, dodecyl-,calcium salt), purity 69-71%.

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
Rat (Sprague-Dawley), weight 200-300 g.

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Details on oral exposure:
Single dose by oral gavage of 1.0, 1.5, 2.0, 2.5 and 3.0 mL/kg bw.
Doses:
1.0, 1.5, 2.0, 2.5 and 3.0 mL/kg bw.
No. of animals per sex per dose:
5/sex/dose group.
Control animals:
yes
Details on study design:
Mortality/clinical signs daily for 14 days. Body weight on day 0 and 14. Macroscopy on animals that died.
Statistics:
Litchfield-Wilcoxin (Probit analysis).

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
1 300 mg/kg bw
Based on:
act. ingr.
Mortality:
Motaliity was not affected.
Clinical signs:
A high incidence of diarrhea was noted with the use of the higher concentration. Those rats which succumbed appeared to be weak and showed reduced voluntary activity prior to death.
Body weight:
Those rats which succumbed appeared to be weak and showed reduced voluntary activity prior to death, whereas those that survived showed good weight increases during the 14-day period.
Gross pathology:
No significant gross abnormalities were seen at autopsy.

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
The acute oral LD50 in male/female rats is 1300 mg/kg bw. No significant gross abnormalities were seen at autopsy.
LD50-rat 1.8 mL/kg ⇔ 1.3 g a.i./kg = 1300 mg/kg bw
Executive summary:

The acute oral LD50 in male/female rats is 1300 mg/kg bw. No significant gross abnormalities were seen at autopsy.

LD50-rat 1.8 mL/kg ⇔ 1.3 g a.i./kg = 1300 mg/kg bw

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