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Diss Factsheets

Administrative data

Endpoint:
epidemiological data
Type of information:
other: published data
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Justification for type of information:
C12 LAS; Linear Alkylbenzene Sulfonate (LAS)) is a very close analogue of Calcium dodecylbenzenesulfonate (CAS No 26264-06-2, EC Number; 247-557-8) ) and read-across is valid.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1990

Materials and methods

Study type:
cross sectional study
Endpoint addressed:
skin irritation / corrosion
skin sensitisation
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Method:In a review of 1 581 540 cases of human exposure to a wide range of chemicals reported by the United States Poison Control Centers in 1989, 7983 people had been exposed to household automatic dishwasher preparations (alkali, anionic or nonionic, other or unknown) and 506 had required treatment in a health facility; 8950 had been exposed to household cleansers, with 894 requiring treatment; 12 876 had been exposed to laundry preparations, with 1542 treated; and 621 had been exposed to industrial detergents (anionic, cationic, nonionic), with 321 cases requiring treatment.
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
C12-LAS
IUPAC Name:
C12-LAS
Details on test material:
C12-LAS

Method

Type of population:
general
Ethical approval:
no
Details on study design:
In a review of 1 581 540 cases of human exposure to a wide range of chemicals reported by the United States Poison Control Centers in 1989, 7983 people had been exposed to household automatic dishwasher preparations (alkali, anionic or nonionic, other or unknown) and 506 had required treatment in a health facility; 8950 had been exposed to household cleansers, with 894 requiring treatment; 12 876 had been exposed to laundry preparations, with 1542 treated; and 621 had been exposed to industrial detergents (anionic, cationic, nonionic), with 321 cases requiring treatment.
Exposure assessment:
estimated

Results and discussion

Results:
There were no deaths, and only 12 of the treated cases were classified as 'major outcome'. Virtually all the reports involved accidental exposure. The compositions of the cleaning preparations, routes of exposure, and clinical descriptions were not provided

Applicant's summary and conclusion

Conclusions:
There were no deaths, and only 12 of the treated cases were classified as 'major outcome'. Virtually all the reports involved accidental exposure. The compositions of the cleaning preparations, routes of exposure, and clinical descriptions were not provided
Executive summary:

EFFECTS ON HUMANS

 Summary

 Human skin can tolerate contact with solutions of up to 1% LAS for 24 h with only mild irritation. Like other surfactants, LAS can deliapidate the skin surface, elute natural moisturizing factor, denature the proteins of the outer epidermal layer, and increase permeability and swelling of the outer layer. LAS do not induce skin sensitization in humans, and there is no conclusive evidence that they induce eczema. No serious injuries or fatalities have been reported following accidental ingestion of LAS-containing surfactant preparations.

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