Registration Dossier
Registration Dossier
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EC number: 247-557-8 | CAS number: 26264-06-2
Specific investigations: other studies
Administrative data
- Endpoint:
- biochemical or cellular interactions
- Type of information:
- other: published data
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Sodium dodecylbenzenesulfonate (CAS# 25155-30-0 , EC Number; 246-680-4 ) is a very close analogue of Calcium dodecylbenzenesulfonate (CAS No 26264-06-2, EC Number; 247-557-8) ) and read-across is valid.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 972
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Method:The effects of LAS (sodium dodecylbenzenesulfonate) on fasting blood glucose level and glucose tolerance curves were investigated in 40 male and 50 female albino rats pretreated with 0.25 g/kg body weight per day of LAS for three months. At the end of this period, the rats were divided into four groups and given distilled water, 6.1 g/kg body weight of glucose, 0.94 g/kg body weight of LAS, or 6.1 g/kg body weight of glucose plus 0.94 g/kg body weight of LAS by gavage. Blood glucose was then estimated at 30-min intervals.
- GLP compliance:
- not specified
- Type of method:
- in vivo
- Endpoint addressed:
- basic toxicokinetics
Test material
- Reference substance name:
- Sodium dodecylbenzenesulfonate
- EC Number:
- 246-680-4
- EC Name:
- Sodium dodecylbenzenesulfonate
- Cas Number:
- 25155-30-0
- Molecular formula:
- C18H30NaO3S
- IUPAC Name:
- sodium dodecylbenzenesulfonate
- Details on test material:
- - Name of test material (as cited in study report):sodium dodecylbenzenesulfonate.
Sodium dodecylbenzenesulfonate (CAS# 25155-30-0 , EC Number; 246-680-4 ) is a very close analogue of Calcium dodecylbenzenesulfonate (CAS No 26264-06-2, EC Number; 247-557-8) ) and read-across is valid.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: albino rats
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- -40 male and 50 female albino rats
-avarage weight at study initiation: 160 g and 180 g
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: distilled water, glucose
- Details on exposure:
- The effects of LAS (sodium dodecylbenzenesulfonate) on fasting blood glucose level and glucose tolerance curves were investigated in 40 male and 50 female albino rats pretreated with 0.25 g/kg body weight per day of LAS for three months. At the end of this period, the rats were divided into four groups and given distilled water, 6.1 g/kg body weight of glucose, 0.94 g/kg body weight of LAS, or 6.1 g/kg body weight of glucose plus 0.94 g/kg body weight of LAS by gavage. Blood glucose was then estimated at 30-min intervals.
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- three months
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.25 g/kg body weight
Basis:
nominal conc.
- No. of animals per sex per dose:
- 40 male and 50 female albino rats
- Control animals:
- yes
- Details on study design:
- see attached file
Examinations
- Examinations:
- The effects of LAS (sodium dodecylbenzenesulfonate) on fasting blood glucose level and glucose tolerance curves were investigated in 40 male and 50 female albino rats pretreated with 0.25 g/kg body weight per day of LAS for three months. At the end of this period, the rats were divided into four groups and given distilled water, 6.1 g/kg body weight of glucose, 0.94 g/kg body weight of LAS, or 6.1 g/kg body weight of glucose plus 0.94 g/kg body weight of LAS by gavage. Blood glucose was then estimated at 30-min intervals.
Results and discussion
- Details on results:
- Administration of LAS in conjunction with glucose resulted in higher initial levels of blood glucose in male rats and persistently higher levels in females than did administration of glucose alone. Females in control and pretreated groups generally had higher blood glucose levels in response to administration of glucose or LAS plus glucose than did male rats
Applicant's summary and conclusion
- Conclusions:
- Administration of LAS in conjunction with glucose resulted in higher initial levels of blood glucose in male rats and persistently higher levels in females than did administration of glucose alone. Females in control and pretreated groups generally had higher blood glucose levels in response to administration of glucose or LAS plus glucose than did male rats
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