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Administrative data

Endpoint:
biochemical or cellular interactions
Type of information:
other: published data
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Justification for type of information:
Sodium dodecylbenzenesulfonate (CAS# 25155-30-0 , EC Number; 246-680-4 ) is a very close analogue of Calcium dodecylbenzenesulfonate (CAS No 26264-06-2, EC Number; 247-557-8) ) and read-across is valid.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1972

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Method:The effects of LAS (sodium dodecylbenzenesulfonate) on fasting blood glucose level and glucose tolerance curves were investigated in 40 male and 50 female albino rats pretreated with 0.25 g/kg body weight per day of LAS for three months. At the end of this period, the rats were divided into four groups and given distilled water, 6.1 g/kg body weight of glucose, 0.94 g/kg body weight of LAS, or 6.1 g/kg body weight of glucose plus 0.94 g/kg body weight of LAS by gavage. Blood glucose was then estimated at 30-min intervals.
GLP compliance:
not specified
Type of method:
in vivo
Endpoint addressed:
basic toxicokinetics

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium dodecylbenzenesulfonate
EC Number:
246-680-4
EC Name:
Sodium dodecylbenzenesulfonate
Cas Number:
25155-30-0
Molecular formula:
C18H30NaO3S
IUPAC Name:
sodium dodecylbenzenesulfonate
Details on test material:
- Name of test material (as cited in study report):sodium dodecylbenzenesulfonate.
Sodium dodecylbenzenesulfonate (CAS# 25155-30-0 , EC Number; 246-680-4 ) is a very close analogue of Calcium dodecylbenzenesulfonate (CAS No 26264-06-2, EC Number; 247-557-8) ) and read-across is valid.

Test animals

Species:
rat
Strain:
other: albino rats
Sex:
male/female
Details on test animals or test system and environmental conditions:
-40 male and 50 female albino rats
-avarage weight at study initiation: 160 g and 180 g

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: distilled water, glucose
Details on exposure:
The effects of LAS (sodium dodecylbenzenesulfonate) on fasting blood glucose level and glucose tolerance curves were investigated in 40 male and 50 female albino rats pretreated with 0.25 g/kg body weight per day of LAS for three months. At the end of this period, the rats were divided into four groups and given distilled water, 6.1 g/kg body weight of glucose, 0.94 g/kg body weight of LAS, or 6.1 g/kg body weight of glucose plus 0.94 g/kg body weight of LAS by gavage. Blood glucose was then estimated at 30-min intervals.
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
three months
Frequency of treatment:
daily
Doses / concentrations
Remarks:
Doses / Concentrations:
0.25 g/kg body weight
Basis:
nominal conc.
No. of animals per sex per dose:
40 male and 50 female albino rats
Control animals:
yes
Details on study design:
see attached file

Examinations

Examinations:
The effects of LAS (sodium dodecylbenzenesulfonate) on fasting blood glucose level and glucose tolerance curves were investigated in 40 male and 50 female albino rats pretreated with 0.25 g/kg body weight per day of LAS for three months. At the end of this period, the rats were divided into four groups and given distilled water, 6.1 g/kg body weight of glucose, 0.94 g/kg body weight of LAS, or 6.1 g/kg body weight of glucose plus 0.94 g/kg body weight of LAS by gavage. Blood glucose was then estimated at 30-min intervals.

Results and discussion

Details on results:
Administration of LAS in conjunction with glucose resulted in higher initial levels of blood glucose in male rats and persistently higher levels in females than did administration of glucose alone. Females in control and pretreated groups generally had higher blood glucose levels in response to administration of glucose or LAS plus glucose than did male rats

Applicant's summary and conclusion

Conclusions:
Administration of LAS in conjunction with glucose resulted in higher initial levels of blood glucose in male rats and persistently higher levels in females than did administration of glucose alone. Females in control and pretreated groups generally had higher blood glucose levels in response to administration of glucose or LAS plus glucose than did male rats

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