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Short-term toxicity to fish

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Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 203 (Fish, Acute Toxicity Test)
GLP compliance:
yes
Analytical monitoring:
not specified
Vehicle:
yes
Test organisms (species):
Cyprinus carpio
Details on test organisms:
SPECIES #
(NAME): 21 Cyprinus carpio
(Common Carp)
AGE: NR
LIFE STAGE: not reported, unknown
COMMENT: 5.5 CM, 1.8 G
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
48 h
Hardness:
18mg/L
Test temperature:
21±1.8℃
pH:
7.1±0.2
Dissolved oxygen:
6.5-8.4ppm
Reference substance (positive control):
not specified
Key result
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
2.8 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Key result
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
4.2 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Validity criteria fulfilled:
yes
Conclusions:
Under static conditions the LC50 in Cyprinus carpio was between 2.8 mg/l and 4.2 mg/l for Calcium dodecylbenzenesulphonate which is moderate toxicity .
Endpoint:
short-term toxicity to fish
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
QSAR prediction: US EPA accepted QSAR method for chemicals properties assessment.
Qualifier:
according to guideline
Guideline:
other: QSAR
Principles of method if other than guideline:
EPI Suite v 4.1/ECOSARv1.00
GLP compliance:
no
Remarks:
not applicable to QSAR models
Analytical monitoring:
not specified
Vehicle:
not specified
Test organisms (species):
other: Fishes species
Details on test organisms:
no further information
Test type:
other: QSAR model
Water media type:
freshwater
Limit test:
no
Total exposure duration:
96 h
Hardness:
not applicable. QSAR model
Test temperature:
not applicable. QSAR model
pH:
not applicable. QSAR model
Dissolved oxygen:
not applicable. QSAR model
Salinity:
not applicable. QSAR model
Details on test conditions:
100% : Benzenesulfonic acid, dodecyl-, calcium salt
CAS Number: 26264-06-2
SMILES : CCCCCCCCCCCCc1ccc(S(=O)(=O)OOS(=O)(=O)c2ccc(CCCCCCCCCCCC)cc2)cc1
CHEM : Benzenesulfonic acid, dodecyl-, calcium salt
MOL FOR: C36 H58 O6 S2 Ca1
MOL WT : 691.06
Wat Sol: 0.006264 (mg/L, EPISuite WSKowwin v1.43 Estimate)
Log Kow: 4.770
Remarks: Anionic surfactant – alkyl benzene sulfonates; effective alkyl chain length = C12




Reference substance (positive control):
no
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
1.74 mg/L
Nominal / measured:
not specified
Conc. based on:
not specified
Basis for effect:
not specified
Details on results:
Using the EPIWIN ECOSAR QSAR model, a 96hr LC50 for freshwater fish of 1.74 mg/l was established.
Fish, 96-hr LC50 =1.74 mg/L (ppm)
Results with reference substance (positive control):
The ECOSAR QSAR model predicts that the 96hr LC50 for freshwater fish would to be 1.74 mg/l therefore that the substance is moderately toxic to fishes.
Validity criteria fulfilled:
yes
Remarks:
US EPA accepted QSAR method for chemicals properties assessment.
Conclusions:
Using the EPIWIN ECOSAR QSAR model, a 96hr LC50 for freshwater fish of 1.74 mg/l was established.
Fish, 96-hr LC50 =1.740 mg/L (ppm)
Fish 30-day ChV = 0.230mg/L (ppm)

Executive summary:

The ECOSAR QSAR model predicts that the 96hr LC50 for freshwater fish would to be 1.74 mg/l therefore that the substance is moderately toxic to fishes.

Description of key information

Under static conditions the LC50 in Cyprinus carpio was between 2.8 mg/l  and 4.2 mg/l  for Calcium dodecylbenzenesulphonate which is moderate toxicity .
Under static conditions the LC50 in Oryzias latipes was between 3 mg/l and 5.3 mg/l for Calcium dodecylbenzenesulphonate which is moderate toxicity .
Under static conditions the LC50 in Misgurnus anguillicaudatus was between 3.3 mg/l and 6 mg/l for Calcium dodecylbenzenesulphonate which is moderate toxicity .
The ECOSAR QSAR model predicts that the 96hr LC50 for freshwater fish would to be 1.74 mg/l therefore that the substance is moderately toxic to fishes.
The available data for saltwater fishes a are limited and to obtaine the value for PNECs for saltwaters is taken account a assesment factor 10 to extrapolate to LC50 following the “Guidance on Information Requirement and Chemical Safety Assessment R.10: Characterisation of dose [concentration]- response for environment”and “Table R.10-5 Assessment factors proposed for deriving PNEC water for saltwater for different data sets”, to account for the possibility that greater taxonomic diversity in the marine environment makes it likely that some marine taxa may be more sensitive than the most sensitive freshwater taxa

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
2.8 mg/L

Marine water fish

Marine water fish
Effect concentration:
0.28 mg/L

Additional information

Under static conditions the LC50 in Cyprinus carpio was between 2.8 mg/l and 4.2 mg/l for Calcium dodecylbenzenesulphonate which is moderate toxicity .

 

Under static conditions the LC50 in Oryzias latipes was between 3 mg/l and 5.3 mg/l for Calcium dodecylbenzenesulphonate which is moderate toxicity .

 

Under static conditions the LC50 in Misgurnus anguillicaudatus  was between 3.3 mg/l and 6 mg/l for Calcium dodecylbenzenesulphonate which is moderate toxicity .

 

The ECOSAR QSAR model predicts that the 96hr LC50 for freshwater fish would to be 1.74 mg/l therefore that the substance is moderately toxic to fishes.

 

The available data for saltwater fishes a are limited and to obtaine the value for PNECs for saltwaters is taken account a assesment factor 10 to extrapolate to LC50 following the “Guidance on Information Requirement and Chemical Safety Assessment R.10: Characterisation of dose [concentration]- response for environment”and “Table R.10-5 Assessment factors proposed for deriving PNEC water for saltwater for different data sets”, to account for the possibility that greater taxonomic diversity in the marine environment makes it likely that some marine taxa may be more sensitive than the most sensitive freshwater taxa