Calcium dodecylbenzenesulphonate

Hydrolysis

Link to relevant study record(s)

Reference

Endpoint:

hydrolysis

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Justification for type of information:

Dodecylbenzene sulfonic acids (CAS# 27176-87-0 , EC Number; 248-289-4) ) is a very close analogue of Calcium dodecylbenzenesulfonate (CAS No 26264-06-2, EC Number;247-557-8) ) and the dissociated acid it readily dissociates in water and release the dodecylbenzene sulfonic anion in solution.

Reason / purpose for cross-reference:

read-across source

Qualifier:

according to guideline

Guideline:

OECD Guideline 111 (Hydrolysis as a Function of pH)

GLP compliance:

yes

Radiolabelling:

not specified

Analytical monitoring:

yes

Buffers:

Buffer solution were sterilized through the 0.2 μm cellulose acetate filter. The composition of buffer solutions was as follows:- pH 4.0 : 0.1 N NaOH 0.4 mL + 0.1 M Potassium biphthalate 50 mL Dissolved in deionized water and made up to 100 mL- pH 7.0 : 0.1 N NaOH 29.63ml + 0.1 M Monopotassium 50 mL Dissolved in deionized water and made up to 100 mL- pH 9.0 : 0.1 N NaOH 21.3ml + 0.1 Boric acid in 0.1 M KCl 50 mL Dissolved in deionized water and made up to 100 mL

Details on test conditions:

All glassware used in the hydrosis test were sterilized and buffer solutions were taken to avoid oxygen and all of the Hydrosis test was carried out under dark condition.

Preliminary study:

Triplicate sterile aqueous buffer solutions (250 mL) of different pH values of 4.0, 7.0 and 9.0 were treatedwith test substance to make 50 ppm.The test was performed at 50 +/- 5 deg C for 5 days. Individual replicate samples were sampled at application (0 day) and 5 days.And samples were quantified by HPLC.

Transformation products:

no

pH:

4

Temp.:

50 °C

DT50:

> 1 yr

Type:

(pseudo-)first order (= half-life)

Remarks on result:

other: The hydrolysis of the substance was less than 10% over the 5 days, so a definitive test was not performed. Based on these results, dodecylbenzenesulfonic acid was hydrolytically stable (half life > 1 year) specified by the OECD Guidelines.

pH:

7

Temp.:

50 °C

DT50:

> 1 yr

Type:

(pseudo-)first order (= half-life)

Remarks on result:

other: The hydrolysis of the substance was less than 10% over the 5 days, so a definitive test was not performed. Based on these results, dodecylbenzenesulfonic acid was hydrolytically stable (half life > 1 year) specified by the OECD Guidelines.

pH:

9

Temp.:

50 °C

DT50:

> 1 yr

Type:

(pseudo-)first order (= half-life)

Remarks on result:

other: The hydrolysis of the substance was less than 10% over the 5 days, so a definitive test was not performed. Based on these results, dodecylbenzenesulfonic acid was hydrolytically stable (half life > 1 year) specified by the OECD Guidelines.

Details on results:

The preliminary test results showed that the percent hydrolysis at pH 4.0, 7.0 and 9.0 were negative values after 5 days respectively. These results were less than 10% of hydrolysis and then test substance was considered hydrolytically stable and no additional testing was requiredby the OECD Guidelines.

Validity criteria fulfilled:

yes

Conclusions:

Since the chemical is degradable less than 10% after 5 days in this test condition, it is presumably stable in water. (Hydrolytically stable)

Executive summary:

This study was performed following “OECD Guidelines for Testing of Chemicals No. 111: Hydrolysis as function of pH. The preliminary test was performed at 50 ±5°C and pH 4, 7 and pH 9. The hydrolysis of the substance was less than 10% over the 5 days, so a definitive test was not performed. Based on these results, dodecylbenzenesulfonic acid was hydrolytically stable (half life > 1 year) specified by the OECD Guidelines

Description of key information

The study of MOE 2008 was performed following “OECD Guidelines for Testing of Chemicals No. 111: Hydrolysis as function of pH. The preliminary test was performed at 50 ±5°C and pH 4, 7 and pH 9. The hydrolysis of the substance was less than 10% over the 5 days, so a definitive test was not performed. Based on these results, dodecylbenzenesulfonic acid was hydrolytically stable (half life > 1 year) specified by the OECD Guidelines Dodecylbenzene sulfonic acids (CAS# 27176-87-0 , EC Number; 248-289-4) ) is a very close analogue of Calcium dodecylbenzenesulfonate (CAS No 26264-06-2,  EC Number;247-557-8) ) and the dissociated acid it readily dissociates in water and release the dodecylbenzene sulfonic anion in solution.

Key value for chemical safety assessment

Half-life for hydrolysis:

1 yr

at the temperature of:

50 °C

Additional information

The study of MOE 2008 was performed following “OECD Guidelines for Testing of Chemicals No. 111: Hydrolysis as function of pH. The preliminary test was performed at 50 ±5°C and pH 4, 7 and pH 9. The hydrolysis of the substance was less than 10% over the 5 days, so a definitive test was not performed. Based on these results, dodecylbenzenesulfonic acid was hydrolytically stable (half life > 1 year) specified by the OECD Guidelines .Dodecylbenzene sulfonic acids (CAS# 27176-87-0 , EC Number; 248-289-4) ) is a very close analogue of Calcium dodecylbenzenesulfonate (CAS No 26264-06-2, EC Number;247-557-8) ) and the dissociated acid it readily dissociates in water and release the dodecylbenzene sulfonic anion in solution.