Registration Dossier
Registration Dossier
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EC number: 807-040-5 | CAS number: 4538-42-5
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics, other
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- ANALOGUE APPROACH JUSTIFICATION
See document attached to section "13.2 Other assessment reports"
Cross-reference
- Reason / purpose for cross-reference:
- read-across source
Reference
- Endpoint:
- basic toxicokinetics
- Type of information:
- other: toxikokinetics assessment
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The assessment of the toxicokinetics of HDI is based on experimental toxicokinetic studies in animals and volunteers. In addition, further toxicological data as well as physico-chemical properties of the compound were taken into account.
- Justification for type of information:
- ANALOGUE APPROACH JUSTIFICATION
See document attached to this endpoint study record - Principles of method if other than guideline:
- assessment on toxicokinetics
For an assessment of toxicokinetics read across is performed to HDI (CAS no. 822 -06 -0). For that purpose, the toxicokinetic assessment of HDI, which is based on experimental toxicokinetic studies in animals and volunteers, physico-chemical properties, and further toxicological data, is cited below. Given that the read across is justified, this is favourable to a toxicokinetic assessment solely based on PDI data, since the toxicokinetic database of HDI is much broader than that of PDI.
(For justification of read across see document attached to section 13.2 Other assessment reports.)
Data source
Materials and methods
Test material
- Reference substance name:
- 1,5-Diisocyanatopentane
- EC Number:
- 807-040-5
- Cas Number:
- 4538-42-5
- Molecular formula:
- C7H10N2O2
- IUPAC Name:
- 1,5-Diisocyanatopentane
- Test material form:
- liquid
Constituent 1
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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