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Physical & Chemical properties

Density

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Reference
Endpoint:
relative density
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From April 27th to April 29th, 2016.
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
Method according to EU method A.3, with GLP.
Qualifier:
according to guideline
Guideline:
EU Method A.3 (Relative Density)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
pycnometer method
Remarks:
Gay-Lussac pycnometer (ISO 3507:1999)
Type:
density
Density:
1.522 g/cm³
Temp.:
20 °C
Key result
Type:
relative density
Density:
1.522 other: no units
Temp.:
20 °C

Table 1. Results of density determination for theobromine.

Test No.

Mass of empty pycnometer

 

mo

Mass of pycnometer with water

 

m1

Mass of pycnometer with immersing liquid,

 

m2

Mass of pycnometer with tested material

 

m3

Mass of pycnometer with tested material and immersing liquid,

m4

Density

[g]

[g]

[g]

[g]

[g]

[g/mL]

1

24.1476

49.4098

44.1278

29.4883

46.7025

1.5225

2

24.1482

49.4096

44.1233

28.6345

46.2843

1.5211

 

 

 

 

 

Average

1.522

Table 2. Summary of results.

Test

Guideline and method

Findings

Relative density

EEC A.3 (CIPAC MT 3.2)

Absolute - 1.522 g/mL

Relative  - 1.522
Conclusions:
The relative density of theobromine is 1.522 at 20ºC.
Executive summary:

The density of theobromine was determined using the Gay-Lussac pycnometer in accordance with EEC Method A3 (CIPAC MT 3.2.1). The mass of the substance occupying a unit volume at 20˚C (GLP study) was measured. The average measured absolute density at 20°C was 1.522 g/mL, and the average calculated relative density at 20°C temperature was 1.522.

Description of key information

Key study. EU Method A.3. GLP study. The relative density at 20 ºC was 1.522.

Key value for chemical safety assessment

Relative density at 20C:
1.522

Additional information

Key study: The density theobromine was determined using the Gay-Lussac pycnometer in accordance with EEC Method A3 (CIPAC MT 3.2.1) (GLP study). The average measured absolute density at 20°C was 1.522 g/mL, and the average calculated relative density at 20°C was 1.522.