Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
07 April 2015 - 29 May 2015
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP-compliant study in accordance with EC A.8.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2015
Report Date:
2015

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient)
Version / remarks:
(2008)
Deviations:
no
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Version / remarks:
(2004)
Deviations:
no
Qualifier:
according to
Guideline:
EPA OPPTS 830.7570 (Partition Coefficient, n-octanol / H2O, Estimation by Liquid Chromatography)
Version / remarks:
(1996)
Deviations:
no
GLP compliance:
yes
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name (as cited in study report): NS-1000
- Appearance: Clear colourless liquid

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
5.3
pH:
7
Remarks on result:
other: Pow = 1.8 E05
Details on results:
In the chromatogram of the test substance solution, one peak with a retention time of 5.0 minutes was observed. No substance related peak was observed in the chromatogram of the test substance blank.

Any other information on results incl. tables

Table: Results HPLC method for partition coefficient n-octanol-water:

 

Substance

tr,1

[min.]

tr,2

[min.]

Mean tr

[min.]

Log Pow

Pow

Formamide (t0)

0.674

0.676

0.675

 

 

1,4-Dichlorobenzene

1.845

1.839

 

3.4

Biphenyl

2.442

2.436

4.0

1,2,4-Trichlorobenzene

2.805

2.798

4.2

Dibenzyl

3.964

3.957

4.8

Triphenylamine

7.173

7.167

5.7

4,4’-DDT

10.088

10.082

6.5

Test substance

5.010

5.006

5.008

5.3

1.8 x 105

 

Applicant's summary and conclusion

Conclusions:
In a GLP-compliant study in accordance with EC A.8, OECD 117 and EPA OPPTS 830.7570 using the HPLC method, the log Pow of the substance has been determined as 5.3.