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Ecotoxicological information

Long-term toxicity to aquatic invertebrates

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Reference
Endpoint:
long-term toxicity to aquatic invertebrates
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Justification for type of information:
Calculation of the combined chronic toxicity values of individual alkyl lactates (chVs) based on ECOSAR predicted ChVs and assuming equal fractions of alkyl lactates.
Principles of method if other than guideline:
Calculation based on ECOSAR v1.1 Class-specific Estimations
Analytical monitoring:
not required
Vehicle:
no
Test organisms (species):
Daphnia magna
Test type:
other: QSAR calculations
Duration:
21 d
Dose descriptor:
other: ChV = 10^([log (LOEC x NOEC)]/2)
Effect conc.:
0.088 mg/L
Nominal / measured:
estimated
Conc. based on:
other: equal fractions of lactates
Basis for effect:
not specified
Remarks on result:
other: Ester based
Key result
Duration:
21 d
Dose descriptor:
other: ChV = 10^([log (LOEC x NOEC)]/2)
Effect conc.:
0.023 mg/L
Nominal / measured:
estimated
Conc. based on:
other: equal fractions of lactates
Basis for effect:
not specified
Remarks on result:
other: Neutral Organic SAR (Baseline Toxicity)
Details on results:
Daphnia chronic Ester Class
Lactate CHV 1/CHV f f/CHV
Dodecyl lactate 0.427 2.34192 0.25 0.5855
Tridecyllactate 0.192 5.20833 0.25 1.3021
Tetradecyllactate 0.086 11.62791 0.25 2.9070
Pentadecyllactate 0.038 26.31579 0.25 6.5789
Σf/CHV 11.3735
CHV Ceraphyl 41 0.0879

Daphnia chronic Neutral Organic SAR (Baseline Toxicity)
Lactate CHV 1/CHV f f/CHV
Dodecyl lactate 0.108 9.25926 0.25 2.3148
Tridecyllactate 0.049 20.40816 0.25 5.1020
Tetradecyllactate 0.022 45.45455 0.25 11.3636
Pentadecyllactate 0.01 100.00000 0.25 25.0000
Σf/CHV 43.7805
CHV Ceraphyl 41 0.0228
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ECOSAR v1.1 Class-specific Estimations
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Dodecyl lactate:

Esters Class:                   Daphnid                    ChV        0.427 mg/L

Neutral Organic SAR (Baseline Toxicity): Daphnid                    ChV        0.108  mg/L

Tridecyl lactate:

Esters Class:                   Daphnid                    ChV        0.192 mg/L

Neutral Organic SAR (Baseline Toxicity): Daphnid                    ChV        0.049 mg/L

Tetradecyl lactate:

Esters Class:                   Daphnid                    ChV        0.086 mg/L

Neutral Organic SAR (Baseline Toxicity): Daphnid                    ChV        0.022 mg/L

Pentadecyl lactate:

Esters Class:                   Daphnid                    ChV        0.038 mg/L

 Neutral Organic SAR (Baseline Toxicity): Daphnid                      ChV        0.010 mg/L

Description of key information

The key value for C12 -15 alkyl lactates is calculated using the ECOSAR estimated chronic values for these alkyl lactates.

Key value for chemical safety assessment

EC10, LC10 or NOEC for freshwater invertebrates:
0.023 mg/L

Additional information

Concerning long-term toxicity of C12 -15 alcohols for invertebrates, the NOEC for reproduction of Daphnia magna was found at 0.0063 mg/L for C14 alcohol (measured concentrations) and 1.0 mg/L for C12 alcohol. Based on the maximum concentration of C12 -15 alcohols in the UVCB under registration, the worst case NOEC is 0.063 mg/L based on the alcohols. Since this value is higher than the predicted NOEC for the C12 -15 alkyl lactates, the latter is chosen as the key value for the UVCB under registration.