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EC number: 812-038-2 | CAS number: 1192651-80-1
There were no deaths. No signs of systemic toxicity were noted in the test or control animals during the test. Bodyweight changes of the test animals between day 1 and day 6 were comparable to those observed in the corresponding control group animals over the same period.
An LLNA skin sensitisation study was performed according to OECD/EC test guidelines and GLP principles. Based on the results of a pre-screen test, the test concentrations were selected at 5%, 10% and 25% w/w. In the preliminary test, no skin irritation was observed at 25% w/w. No mortality occurred and no clinical signs of systemic toxicity were observed in the animals of the main study. Body weights and body weight gain of experimental animals remained in the same range as controls over the study period. Mean DPM/animal values for the experimental groups treated with test item concentrations 5, 10 and 25% were 12358, 15185 and 11319 DPM, respectively. The mean DPM/animal value for the vehicle control group was 16493 DPM. The SI values calculated for the test item concentrations 5, 10 and 25% were 0.75, 0.92 and 0.69, respectively. As the SI was < 3 when tested up to 25% w/w, NXL104 is considered not to be a skin sensitiser.
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