Registration Dossier
Registration Dossier
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EC number: 203-862-8 | CAS number: 111-36-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary literature
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Data to substantiate the maximum allowable concentrations of m-Trifluoromethylphenyl Isocyanate and Butyl Isocyanate in the air of work areas.
- Author:
- Gurova AI, Alekseeva NP, Gorlova OE, Chernyshova RA
- Year:
- 1 976
- Bibliographic source:
- Gig Tr Prof Zabol 3: 53-55, cited in Emergency Response Planning Guidelines Documentation (1994) n-Butylisocyanat. American Industrial Hygiene Association.
Materials and methods
- Principles of method if other than guideline:
- no data
- GLP compliance:
- no
- Test type:
- other: no data
Test material
- Reference substance name:
- Butyl isocyanate
- EC Number:
- 203-862-8
- EC Name:
- Butyl isocyanate
- Cas Number:
- 111-36-4
- Molecular formula:
- C5H9NO
- IUPAC Name:
- 1-isocyanatobutane
- Details on test material:
- n-butyl isocyanate, no data on purity
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Doses:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 600 mg/kg bw
- Mortality:
- no data
- Clinical signs:
- no data
- Body weight:
- no data
- Gross pathology:
- no data
Any other information on results incl. tables
no data
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information
- Executive summary:
LD50 = 600 mg/kg (rat); no further data
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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