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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Comparable to guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1978
Report date:
1978

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
no
Principles of method if other than guideline:
Internal BASF-method was used, which was in large part equivalent to method described in OECD guideline 401
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1-(1,1-dimethylethoxy)-2-methylpropane
EC Number:
251-347-1
EC Name:
1-(1,1-dimethylethoxy)-2-methylpropane
Cas Number:
33021-02-2
Molecular formula:
C8H18O
IUPAC Name:
1-(tert-butoxy)-2-methylpropane
Details on test material:
- Name of test material (as cited in study report): IBTB.

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Gassner
- Weight at study initiation: mean 190 g (males), 180 g (females)
- Diet (e.g. ad libitum): HERILAN-MRH Haltung, Heinrich Eggersmann KG

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: emulsions in 0.5% aqueous CMC with 2-3 drops of Cremophor EL
Details on oral exposure:
VEHICLE
- Concentration in vehicle: 50%
- Amount of vehicle (if gavage): 20, 13.62 ml/kg bw

MAXIMUM DOSE VOLUME APPLIED: 3.8 ml
Doses:
10000, 6810 mg/kg bw
No. of animals per sex per dose:
5
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily obervations
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 10 000 mg/kg bw
Mortality:
No mortalities occured.
Clinical signs:
other: excitement, spastic gait
Gross pathology:
no abnormalities

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: EU