Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 802-122-7 | CAS number: 4494-16-0
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
LC50 (96 h) > 100 mg/L for Cyprinus carpio (OECD 203), read-across with analogue substance (Z)-9-Octadecen-1,18-dioic acid (CAS 20701-68-2)
Key value for chemical safety assessment
Additional information
Since no studies investigating the short-term toxicity of octadec-9-enedioic acid (EC 802-22-7) to fish are available, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read-across to the structurally related source substance (Z)-9-Octadecen-1,18-dioic acid (CAS 20701-68-2) was conducted. The source substance is representative to evaluate the short-term toxicity of octadec-9-enedioic acid (EC 802-22-7) to fish.
Based on their chemical structure, both the target substance (Octadec-9-enedioic acid, EC 802-22-7) and the source substance ((Z)-9-Octadecen-1,18-dioic acid, CAS 20701-68-2), belong to the family of linear monounsaturated dicarboxylic acids. While the target substance contains a cis- and trans-isomer, the source substance consists of the cis-isomer.
This read-across is justified in detail in the overall summary (IUCLID Section 6.1) and within the analogue justification in IUCLID Section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was used for the assessment.
A GLP study according to OECD guideline 203 on the acute toxicity to carp (Cyprinus carpio) was performed with the analogue substance (Z)-9-Octadecen-1,18-dioic acid (CAS 20701-68-2), the cis-isomer of both of the stereo-isomers, under static conditions (Bogers, 2001a).
Carp were exposed to the nominal concentration of 100 mg/L and an untreated control for 96 hours. The test solution was prepared by dissolving the test item in test medium followed by 4 hrs of stirring and filtering. Also unfiltered solutions were tested. No additional solvent was used. The test water was aerated during the 3rd and 4th day of testing.
Analytical monitoring of the test item concentrations during the test were not conducted. All effect concentrations were based on nominal test concentrations. No mortality or visible effects were observed during the test period. The LC50 for filtered and unfiltered test solutions was determined to be > 100 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
