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Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer-reviewed journal

Data source

Reference
Reference Type:
publication
Title:
Acute dermal toxicity of test chemical in rabbits
Author:
D. L. J. Opdyke
Year:
1973
Bibliographic source:
Food and Cosmetics Toxicology,1973

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Acute dermal toxicity test was carried out to study the effects of test chemical on rabbits.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
β-bromostyrene
EC Number:
203-131-3
EC Name:
β-bromostyrene
Cas Number:
103-64-0
Molecular formula:
C8H7Br
IUPAC Name:
β-bromostyrene
Constituent 2
Reference substance name:
β-bromostyrene
IUPAC Name:
β-bromostyrene
Details on test material:
- Name of test material (as cited in study report):β -Bromostyrene ((2-bromovinyl)benzene)
- Molecular formula :C8H7Br
- Molecular weight :183.0473 g/mole
- Substance type:Organic
- Physical state:Liquid
- Impurities (identity and concentrations):0.4%

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
not specified

Administration / exposure

Type of coverage:
other: Dermal
Vehicle:
not specified
Details on dermal exposure:
not specified
Duration of exposure:
not specified
Doses:
6000 mg/kg
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 6 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No mortality observed
Mortality:
No mortality was observed in treated rabbits at 6000 mg/kg bw
Clinical signs:
other: not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
other: not classified
Conclusions:
The LD50 value was considered to be >6000 mg/kg bw,when ratbbits were treated with test chemical by dermal application.
Executive summary:

In acute dermal toxicity study, rabbits were treated with test chemical in the concentration of 6000 mg/kg bw by dermal application.No mortality was observed in treated rabbits at dose 6000 mg/kg bw.Therefore, LD50 value was considered to be >6000 mg/kg bw,when rabbits were treated with test chemical by dermal application.