Registration Dossier
Registration Dossier
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EC number: 203-131-3 | CAS number: 103-64-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is form peer- reviewed journal
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Acute oral toxicity of test chemical in rats
- Author:
- D. L. J. Opdyke
- Year:
- 1 973
- Bibliographic source:
- Food and Cosmetics Toxicology,1973
- Reference Type:
- other: authoritative database
- Title:
- Acute oral toxicity of test chemical in rats
- Author:
- U.S. National Library of Medicine
- Year:
- 2 018
- Bibliographic source:
- Chemidplus Database,U.S. National Library of Medicine,2018
- Reference Type:
- publication
- Title:
- Acute oral toxicity of test chemical in rats
- Author:
- Richard J. Lewis
- Year:
- 2 012
- Bibliographic source:
- Sax's Dangerous Properties of Industrial Materials, 12th Edition, 5 Volume Set,2012
- Reference Type:
- other: authoritative database
- Title:
- Acute oral toxicity of test chemical in rats
- Author:
- Jay A. Brown
- Year:
- 2 018
- Bibliographic source:
- Haz-Map®: Information on Hazardous Chemicals and Occupational Diseases, U.S. National Library of Medicine, October 2018.
- Reference Type:
- other: authoritative database
- Title:
- Acute oral toxicity study of test chemical in Rat
- Author:
- U.S. National Library of Medicine
- Year:
- 2 018
- Bibliographic source:
- HSDB (Hazardous Substances Data Bank); US national Library of Medicine,2018
- Reference Type:
- other: Secondary source
- Title:
- Acute oral toxicity of test chemical in rats
- Author:
- RTECS
- Year:
- 2 018
- Bibliographic source:
- RTECS (registry of toxic effect of chemical substance database), 2018
- Reference Type:
- other: authoritative database
- Title:
- Acute oral toxicity of test chemical in rats
- Author:
- National Center for Biotechnology Information
- Year:
- 2 018
- Bibliographic source:
- PubChem open chemistry database,2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Acute Oral toxicity test was carried out to study the effects of test chemical on rats.
- GLP compliance:
- not specified
- Test type:
- other: no data
- Limit test:
- no
Test material
- Reference substance name:
- β-bromostyrene
- EC Number:
- 203-131-3
- EC Name:
- β-bromostyrene
- Cas Number:
- 103-64-0
- Molecular formula:
- C8H7Br
- IUPAC Name:
- β-bromostyrene
- Reference substance name:
- β-bromostyrene
- IUPAC Name:
- β-bromostyrene
- Details on test material:
- - Name of test material (as cited in study report):β -Bromostyrene ((2-bromovinyl)benzene)
- Molecular formula :C8H7Br
- Molecular weight :183.0473 g/mole
- Substance type:Organic
- Physical state:Liquid
- Impurities (identity and concentrations):0.4%
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- not specified
- Doses:
- 1250 mg/kg bw
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 1 250 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 8 200 - <= 189 000
- Remarks on result:
- other: 50 % mortality observed
- Mortality:
- 50% mortality was observed in treated rat at dose 1250 mg/kg bw.
- Clinical signs:
- other: not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Conclusions:
- The lethal concentration (LD50) value for acute oral toxicity test was considered to be 1250 mg/kg bw (95% CI: 8200-189000),when rats were treated with test chemical orally.
- Executive summary:
Acute oral toxicity study was performed in rats using test chemical.50% mortality was observed at dose 1250 mg/kg bw. Hence,LD50 value was considered to be 1250 mg/kg bw(95% CI: 8200-189000),when rats were treated with test chemical orally.
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