Registration Dossier
Registration Dossier
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EC number: 224-208-8 | CAS number: 4247-02-3
Endpoint summary
Administrative data
Description of key information
LLNA (OECD 429): not sensitising
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
In a LLNA skin sensitisation study (WIL research, 2016), performed according to OECD 429 test guideline and GLP principles, isobutyl 4-hydroxybenzoate was considered not to be a skin sensitiser, as the SI appeared not to be ≥ 3 when tested up to and including 60% (v/v) isobutyl 4-hydroxybenzoate.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
The available data on skin sensitisation do not meet the criteria for classification according to Regulation (EC) 1272/2008 and are threrefore conclusive but not sufficient for classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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