Registration Dossier
Registration Dossier
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EC number: 239-362-1 | CAS number: 15332-99-7
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Tris(isopropenyloxy)(vinyl)silane has been tested for mutagenicity to bacteria, in a study which was conducted according to the OECD TG 471, compliant with GLP (BSL, 2015). No evidence of a test-substance related increase in the number of revertants was observed with or without metabolic activation in Salmonella typhimurium strains TA 98, TA 100, TA 1535, TA 1537 or TA 102 in the initial plate incorporation assay or the repeat experiment using the pre-incubation method, up to limit concentrations. Appropriate positive, solvent and negative (water) controls were included and gave the expected results. It is concluded that the test substance is negative for mutagenicity to bacteria under the conditions of the test.
Justification for selection of genetic toxicity endpoint
The study was conducted according to an appropriate OECD guideline and in compliance with GLP.
Short description of key information:
In vitro:
Gene mutation (Bacterial reverse mutation assay / Ames test): negative with and without metabolic activation in Salmonella typhimurium strains TA 98, TA 100, TA 1535, TA 1537 or TA 102 (OECD TG 471) (BSL, 2015).
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on the available bacterial mutagenicity data, tris(isopropenyloxy)(vinyl)silane does not require classification according to Regulation (EC) No 1272/2008.
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