Tris(isopropenyloxy)vinylsilane

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The study was conducted according to an appropriate OECD test guideline. It was not compliant with GLP.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1983

Report date:

1683

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

tris(isopropenyloxy)(vinyl)silane

IUPAC Name:

tris(isopropenyloxy)(vinyl)silane

Constituent 2

Reference substance name:

Tris(isopropenyloxy)vinylsilane

EC Number:

239-362-1

EC Name:

Tris(isopropenyloxy)vinylsilane

Cas Number:

15332-99-7

Molecular formula:

C11H18O3Si

IUPAC Name:

[tris(isopropenyloxy)vinyl]silane

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Central Institute for the Breeding of Laboratory Animals TNO, Zeist, the Netherlands
- Age at study initiation: no information
- Weight at study initiation: males 85-99g; females 71-90 g
- Fasting period before study: overnight
- Housing: groups of five in stainless steel cages
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 14 days

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 23 +/-1°C
- Humidity (%): 30-70%
- Air changes (per hr): 10
- Photoperiod (hrs dark / hrs light): 12:12

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Doses:

20 ml/kg bw

No. of animals per sex per dose:

10 male and 10 female animals

Control animals:

no

Details on study design:

- Initial screening was conducted to find general level of acute toxicity - results not presented in report.
- Duration of observation period following administration: 14 days.
- Frequency of observations and weighing: clinical observations were frequent in the first 4 hours post-treatment, then at least once daily for the 14 day observation period; weighing was carried out weekly.
- Necropsy of survivors performed: yes - gross examination only.

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 20 mL/kg bw

Based on:

test mat.

Remarks on result:

other: The highest dose tested was 20 ml/kg bw, which is equivalent to approximately 18 g/kg bw

Mortality:

One male rat died on the second day post treatment.

Clinical signs:

other: During the first four hour period sluggishness, ataxia and rough coats were observed. Thereafter most of the rats recovered gradually, looking healthy by end of observation period.

Gross pathology:

Macroscopic examination at autopsy revealed light, discoloured kidneys in all rats. No other treatment-related gross alterations were observed.

Any other information on results incl. tables

Dose test substance (ml/kg bw)	Mean body weight (g) on day						Mortality dead out of 10
	0	7	14	0	7	14
	Males			Females			Males	Females
20	93	135	183	83	123	142	1	0

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

Tris(isopropenyloxy)(vinyl)silane has been tested according to OECD 401. The following clinical signs were observed after ten male and ten female Wistar rats were dosed with 20ml/kg bw: sluggishness; ataxia and rough coats. A single male died on the second day. It is concluded that the LD50 is greater than 20 ml/kg bw, which is equivalent to approximately 18000 mg/kg, based on a density of 0.9 g/cm³.