Registration Dossier
Registration Dossier
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EC number: 239-362-1 | CAS number: 15332-99-7
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 18 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 4 310 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Tris(isopropenyloxy)(vinyl)silane has been tested for acute oral toxicity according to OECD 401 (TNO, 1983); there is no information on GLP compliance. The following clinical signs were observed after ten male and ten female Wistar rats were dosed with 20 ml/kg bw: sluggishness, ataxia and rough coats. A single male died on the second day. It is concluded that the LD50 is >20 ml/kg bw, which is equivalent to approximately 18000 mg/kg, based on a density of 0.9 g/cm3.
Tris(isopropenyloxy)(vinyl)silane has been tested for acute inhalation (aerosol) toxicity in rats in a study conducted according to OECD 403 and in compliance with GLP (RCC, 1989). No mortalities occurred, and treatment-related effects were confined to piloerection and apathy on the day after administration, in the five male and five female rats treated with an aerosol containing 4.31 mg/l of the test substance. It is concluded that the LD50 is >4.31 mg/l under the conditions of the test.
Justification for selection of acute toxicity – oral endpoint
The study was conducted according to a protocol similar to an appropriate OECD guideline. There is no information on GLP compliance.
Justification for selection of acute toxicity – inhalation endpoint
The study was conducted according to an appropriate OECD guideline and in compliance with GLP.
Justification for classification or non-classification
Based on the available studies on acute toxicity, tris(isopropenyloxy)(vinyl)silane does not require classification according to Regulation (EC) No. 1272/2008.
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