Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
18 000 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LC50
Value:
4 310 mg/m³

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Tris(isopropenyloxy)(vinyl)silane has been tested for acute oral toxicity according to OECD 401 (TNO, 1983); there is no information on GLP compliance. The following clinical signs were observed after ten male and ten female Wistar rats were dosed with 20 ml/kg bw: sluggishness, ataxia and rough coats. A single male died on the second day. It is concluded that the LD50 is >20 ml/kg bw, which is equivalent to approximately 18000 mg/kg, based on a density of 0.9 g/cm3.

Tris(isopropenyloxy)(vinyl)silane has been tested for acute inhalation (aerosol) toxicity in rats in a study conducted according to OECD 403 and in compliance with GLP (RCC, 1989). No mortalities occurred, and treatment-related effects were confined to piloerection and apathy on the day after administration, in the five male and five female rats treated with an aerosol containing 4.31 mg/l of the test substance. It is concluded that the LD50 is >4.31 mg/l under the conditions of the test.


Justification for selection of acute toxicity – oral endpoint
The study was conducted according to a protocol similar to an appropriate OECD guideline. There is no information on GLP compliance.

Justification for selection of acute toxicity – inhalation endpoint
The study was conducted according to an appropriate OECD guideline and in compliance with GLP.

Justification for classification or non-classification

Based on the available studies on acute toxicity, tris(isopropenyloxy)(vinyl)silane does not require classification according to Regulation (EC) No. 1272/2008.