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EC number: 246-730-5 | CAS number: 25198-22-5
The eye irritation was determined in an irritation test according to the Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics (1959), the US Association of Food and Drug Officials (AFDO), similar to OECD guideline 405. During the test 3 male and 3 female of Hymalaian rabbit were exposed to the substance as such (3 animals rinsed; 3 animals not rinsed). Approximately 30 seconds after treatment the test item was flushed with 10 ml of physiological saline. The irritation scores were registered after 24, 48, 72 hours, 4 and 7 days and the evaluation of the eye irritatation potential of the test item was conducted considering the mean score following grading at 24, 48 and 72 h for each animal.
After 7 days the irritation effects were reversible only in one animal (rinsed).
Irreversible effects on the eye.
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