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EC number: 246-730-5 | CAS number: 25198-22-5
Due to intensive staining by the test compound erythema was not assessable. For the purpose of calculating the primary irritation index erythema was assumed to be equal to edema based on the correlation existing (Marzulli and Maibach, Fol. Cosm. Tox. 13, 355, 1975).
The skin irritation was determined in an irritation test on rabbits according to the Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics (1959), the US Association of Food and Drug Officials (AFDO), similar to OECD guideline 404. During the test 3 male and 3 female of Hymalaian rabbit were exposed to the substance on intact and abradeed skin, nevertheless in order to evaluate the irritation potential of the substance only the scores registered on intact skin were considered.
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