Registration Dossier
Registration Dossier
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EC number: 246-140-8 | CAS number: 24304-00-5
Endpoint summary
Administrative data
Description of key information
Contact sensitivity to aluminium is very rare. Several review articles report a low incidence of hypersensitization of aluminium compounds even after subcutaneous and intramuscular injections. The risk of hypersensitization after dermal application of a poorly soluble compound like aluminium nitride is considered to be lower compared to subcutaneous injection. Therefore, conducting a vertebrate test with aluminium nitride is considered to be scientifically unjustified and would not respect animal welfare considerations.
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vitro
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Contact sensitivity to aluminium is very rare. Several review articles report a low incidence of hypersensitization of aluminium compounds even after subcutaneous and intramuscular injections. The risk of hypersensitization after dermal application of a poorly soluble compound like aluminium nitride is considered to be lower compared to subcutaneous injection. Therefore, conducting a vertebrate test with aluminium nitride is considered to be scientifically unjustified and would not respect animal welfare considerations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
