Registration Dossier
Registration Dossier
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2,6-bis({[bis(2-hydroxyethyl)amino]methyl})-4-[2-(3-{[bis(2-hydroxyethyl)amino]methyl}-4-hydroxyphenyl)propan-2-yl]phenol; 2,6-bis({[bis(2-hydroxyethyl)amino]methyl})-4-[2-(4-hydroxyphenyl)propan-2-yl]phenol; 2-[(2-hydroxyethyl)amino]ethan-1-ol; 2-{[bis(2-hydroxyethyl)amino]methyl}-4-[2-(3-{[bis(2-hydroxyethyl)amino]methyl}-4-hydroxyphenyl)propan-2-yl]phenol; 2-{[bis(2-hydroxyethyl)amino]methyl}-4-[2-(4-hydroxyphenyl)propan-2-yl]phenol; 4-[2-(4-hydroxyphenyl)propan-2-yl]phenol
EC number: 943-503-9 | CAS number: -
Water solubility
Administrative data
Link to relevant study record(s)
Description of key information
weighted average of water solubility of constituents: 423539 mg/L at 25 °C
water solubility of single constituents:
2,2'-iminodiethanol (Diethanolamine): 1000000 mg/L at 20 °C
2,2-bis(4-hydroxyphenyl)propane (Bisphenol A): 300 mg/L at 25 °C
Mannich Base 1: 10990 mg/L at 25 °C
Mannich Base 2: 12130 mg/L at 25 °C
Mannich Base 3: 3160 mg/L at 25 °C
Key value for chemical safety assessment
- Water solubility:
- 423 539 mg/L
- at the temperature of:
- 25 °C
Additional information
The registration substance is a multi-constituent substance with main constituents Diethanolamine ca. 40 %, Bisphenol A ca .15 %, Mannich Base 1 ca. 26 %, Mannich Base 2 ca. 13 % and Mannich Base 3 ca. 1.5 % as a minor constituent. It is scientifically not reasonable to perform a water solubility test, because the water solubility of the main constituents Diethanolamine und Bisphenol A is well known and published. Furthermore the constituents Mannich Bases undergo decomposition and back reaction in water as examined in a hydrolysis study (Currenta, Neuland, M. study no. 2014/0016/13.)
The water solubility of Diethanolamine is known to be 1000000 mg/L at 20 °C (Dow Chemical, 1980 as cited in HSDB).The water solubility of Bisphenol A is well examined and determined to be 300 mg/L in EU Risk Assessment Report (Bisphenol A, 2010; Shareef, A et al. 2006). The water solubility values at 25 °C of Mannich Base 1 (10990 mg/L), Mannich Base 2 (12130 mg/L) and Mannich Base 3 (3160 mg/L) were calculated with WSKOWWIN v.1.42.
Ca. 40 % of the registration substance is hydrolytically not stable (Mannich Bases) but the water solubility can be calculated. The water solubility of Diethanolamine (ca.40 %) und Bisphenol A (ca.15 %) is well known and suitable for chemical safety assessment. Therefore no water solubility test was performed.
Based on the composition a weighted average value for the water solubility (423539 mg/L at 25 °C) of the test item was derived as key value for chemical safety assessment. The registration substance is considered to be very soluble.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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