Registration Dossier
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EC number: 278-817-9 | CAS number: 78014-16-1
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Using the OECD QSAR Toolbox (version 3.2.0.103) a LC50 of 130 mg/L for fish. An analysis using ECOSAR supports the conclusion that fish is not the most sensitive species towards Triacetonetriamine.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 130 mg/L
Additional information
The acute toxicity on fish of Triacetonetriamine was predicted by using ECOSAR (v1.00) as a suporting analysis in the first place. The LC50 (96 h) was calculated to be 74.82 mg/L for the substance class of aliphatic amine and a LC50 (96 h) of 413.288 mg/L for baseline toxicity (neutral organics SAR). The acute toxicity on daphnid (LC50 = 6.934 mg/L) and green algae (EC50= 2.605 mg/L) were also calculated and revealed that these two species are expected to be more sensitive towards Triacetonetriamine than fish.
For a more detailed analysis, the OECD QSAR Toolbox (version 3.2.0.103, data base version 3.5.0/3.1.2) was used to calculate the acute toxicity on fish by TAT. A LC50 of 130 mg/L was predicted for fish (Pimephales promelas) based on trend analysis. These results demonstrates that the toxicity of TAT is expected to be low and that fish is not the most sensitive species.
Therefore, the two analyses were estimated to be sufficient to cover the endpoint and further testing on vertebrates (fish) has not been performed for animal welfare reasons.
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