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EC number: 248-702-8 | CAS number: 27870-92-4
Endpoint summary
Administrative data
Description of key information
Additional information
Short term toxicity to aquatic invertebrates:
Various predicted studies for the 2-Octadecyl-1H-thioxantheno(2,1,9-def)isoquinoline-1,3(2H)-dione were reviewed to summarize the following information:
48 hrs aquatic toxicity study (SSS QSAR prediction model, 2016) was conducted to assess toxic effects of the 2-Octadecyl-1H-thioxantheno(2,1,9-def)isoquinoline-1,3(2H)-dione (CAS no 27870-92-4) and the results were predicted. The study was based on the effects of the test compound on the Daphnia magna in a static fresh water system. The predicted data suggests the effective concentration (EC50) for the 2-Octadecyl-1H-thioxantheno(2, 1, 9-def) isoquinoline-1, 3(2H)-dione was estimated to be 93.720046997 mg/L on the basis of mobility.
48 hrs aquatic toxicity study (EPI suite, ECOSAR version 1.1, 2016) was conducted to assess toxic effects of the 2-Octadecyl-1H-thioxantheno (2, 1, 9-def) isoquinoline-1, 3(2H)-dione (CAS no 27870-92-4) and the results were predicted. The study was based on the effects of the test compound on the Daphnia magna in a static fresh water system. The predicted data suggests the lethal concentration (LC50) for the 2-Octadecyl-1H-thioxantheno (2, 1, 9-def) isoquinoline-1, 3(2H)-dione was estimated to be 0.000000127 mg/Lon the basis of mobility.
Thus based on above value, it can be concluded that the substance can be considered as toxic to aquatic organisms. Since the substance has a molecular weight of 555.823 g/mol, by speculation, the molecular size of the test substance was so large that reduce the intake rate of chemical into tissues of aquatic biota. Hence, based on this it can be considered that the chemical was not likely to be toxic to aquatic invertebrates at environmentally relevant concentrations and can be classified as non- hazardous as per the criteria of CLP regulation
Toxicity to aquatic algae and cyanobacteria
Various predicted data for the target chemical2-Octadecyl-1H-thioxantheno(2,1,9-def)isoquinoline-1,3(2H)-dione(CAS No. 27870-92-4)were reviewed to summarize the following information:
72 hrs aquatic toxicity study was predicted (SSS QSAR Prediction model, 2016) to assess toxic effects of the test compound 2-Octadecyl-1H-thioxantheno(2,1,9-def)isoquinoline-1,3(2H)-dione (CAS No. 27870 -92 -4) and the results were predicted. The study was based on the effects of the test compound on Pseudokirchnerella subcapitata in a static fresh water system. The predicted data suggests the effective concentration (EC50) for the test compound 2-Octadecyl-1H-thioxantheno(2,1,9-def)isoquinoline-1,3(2H)-dione (CAS No. 27870 -92 -4) was estimated to be 20.2838 mg/l on the basis of growth rate.
Based on the QSAR prediction done using the EPI Suite ECOSAR version 1.10 (EPI suite, 2016), the 96 hours EC50 was estimated to be 0.00000596 mg/l on green algae for substance 2-Octadecyl-1H-thioxantheno(2,1,9-def)isoquinoline-1,3(2H)-dione with growth inhibition effects.
Thus based on above value, it can be concluded that the substance can be considered as toxic to aquatic organisms. Since the substance has a molecular weight of 555.823 g/mol, by speculation, the molecular size of the test substance was so large that reduce the intake rate of chemical into the issues of aquatic biota. Hence, based on this it can be considered that the chemical was non-toxic to aquatic organisms and thus can be classified as non- hazardous as per the CLP criteria.
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