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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
July 1994 - February 1995
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient)
Deviations:
no
GLP compliance:
yes
Type of method:
flask method
Partition coefficient type:
octanol-water
Analytical method:
liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
-3
Temp.:
20 °C
Remarks on result:
other: Standard deviation (%): 6.3

Table 1. Octanol-water partition coefficient determination.

Test No.

Time of equilibration

(h)

Volume of organic phase

(mL)

Concentration of TS in the organic phase

(mg/L)

Volume of aqueous phase

(mL)

Concentration of TS in the aqueous phase

(mg/L)

Partition coefficient at 20ºC

log Partition coefficient

1

3

16

0.5

32

467.9

1.0 E-3

-3.0

2

3

24

1.2

24

935.2

1.3 E-3

-2.9

3

3

32

4.1

16

1986.0

2.1 E-3

-2.7

4

6

16

0.3

32

469.6

0.5 E-3

-3.3

5

6

24

0.9

24

949.5

0.9 E-3

-3.0

6

6

32

2.9

16

1945.3

1.5 E-3

-2.8

Mean

-3.0

SD (%)

6.3

Conclusions:
The partition coefficient (log Pow) of the test substance at 20 ºC was -3.0.
Executive summary:

The partition coefficient test was carried out according to EU Method A 8 Shake-flask method.

The test substance concentrations in the aqueous (MilliQ) and organic (n-octanol) phases were determined by Ion Chromatography.

The partition coefficient (log Pow) of the test substance at 20 ºC was -3.0 with a standard deviation of 6.3%.

Description of key information

Key study: Test method according to EU Method A.8. GLP study.

Key value for chemical safety assessment

Log Kow (Log Pow):
-3
at the temperature of:
20 °C

Additional information

Key study: Test method according to EU Method A 8 Shake-flask method. GLP study. The partition coefficient (log Pow) of the test substance at 20 ºC was -3.0 with a standard deviation of 6.3%.