Registration Dossier

Administrative data

Description of key information

Negative for skin sensitisation (OECD 429)

Negative for respiratory sensitisation

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

Reaction Products of C4 alcohols and C4 alkenes obtained as by-products from the manufacturing of butan-2-ol by sulfuric acid esterification and hydrolysis of butene was assessed for its skin sensitising potential in a Local Lymph Node Assay, according to OECD guideline 429. The test substance was found not to be a skin sensitiser.



Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

No studies on respiratory sensitisation were identified.


There are no reports of respiratory sensitisation from this substance in laboratory animals or humans.

Justification for classification or non-classification

These findings do not warrant the classification of this substance as a skin or respiratory sensitizer under Regulation (EC) 1272/2008 on classification, labelling and packaging of substances and mixtures (CLP).