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Physical & Chemical properties

Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
April 23, 2014
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Principles of method if other than guideline:
The test was performed according to the SOP - STR 071 protocol.
Laser light scattering. The particle size distribution was analyzed using the Mastersizer 2000 tool, which uses the technique of laser diffraction to measures the size of particles. It does this by measuring the intensity of light scattered as a laser beam passes through a dispersed particulate sample. This data is then analyzed to calculate the size of the particles that created the scattering pattern.
GLP compliance:
no
Type of method:
Laser scattering/diffraction
Type of distribution:
volumetric distribution
Percentile:
D10
Mean:
10.411 µm
Remarks on result:
other: Analysis carried out after 2 minutes of ultrasonic treatment.
Percentile:
D50
Mean:
24.249 µm
Remarks on result:
other: Analysis carried out after 2 minutes of ultrasonic treatment.
Percentile:
D90
Mean:
46.835 µm
Remarks on result:
other: Analysis carried out after 2 minutes of ultrasonic treatment.
Conclusions:
d(0.1): 10.411 µm
d(0.5): 24.249 µm
d(0.9): 46.835 µm
Executive summary:

Method

The particle size distribution was analyzed using the Mastersizer 2000 tool according to the SOP - STR 071 protocol, which uses the technique of laser diffraction to measure the size of particles. It does this by measuring the intensity of light scattered as a laser beam passes through a dispersed particulate sample. This data is then analyzed to calculate the size of the particles that created the scattering pattern.

Result

Analysis carried out after 2 minutes of ultrasonic treatment:

d(0.1): 10.411 µm

d(0.5): 24.249 µm

d(0.9): 46.835 µm

Description of key information

MMD: 24.249 µm

Additional information

Laser light scattering