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Hydrolysis

HYDROWIN v2.00 program of Estimation Programs Interface (2018) prediction model was used to predict the hydrolysis half-life of test chemical. The estimated half-life of test chemical was determined to be 5.494 yrs and 200.670 days at pH 7.0 and 8.0 (at 25ᵒC) respectively, indicating that it is not hydrolysable.

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Hydrolysis

Predicted data and various experimental studies of the test chemical were reviewed for the hydrolysis end point which are summarized as below:

 

In aprediction done using the HYDROWIN v2.00 program of Estimation Programs Interface (2018) prediction model was used to predict the hydrolysis half-life of test chemical. The estimated half-life of test chemical was determined to be 5.494 yrs and 200.670 days at pH 7.0 and 8.0 (at 25ᵒC) respectively.

 

In a supporting weight of evidence study from authoritative databases (2016) for the test chemical,the base catalyzed second order hydrolysis rate constant of test chemical was determined using a structure estimation method. The second order hydrolysis rate constant of test chemical was determined to be 0.04 L/mol-sec with a half-life value of 5.0 yrs and 200 days at pH 7.0 and 8.0, respectively.

 

For the test chemical,the base catalyzed second order hydrolysis rate constant of test chemical was determined using a structure estimation method (HSDB, 2017). The second order hydrolysis rate constant of test chemical was determined to be 0.042 L/mol-sec with a half-life value of 5.5 yrs and 200 days at pH 7.0 and 8.0, respectively. 

 

In an another study, the base catalyzed second order hydrolysis rate constant of test chemical was determined using a structure estimation method. The second order hydrolysis rate constant of test chemical was determined to be 0.038 L/mol-sec with a corresponding half-lives of 5.8 years and 210 days at pH 7 and 8, respectively.

 

On the basis of the above results for test chemical, it can be concluded that the hydrolysis half-life value of test chemicalwas evaluated to be 200.670 days (at pH 7.0), indicating that the test chemical is not hydrolysable.

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