Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 407-770-0 | CAS number: 61597-96-4 D(+)-LACTATE D'ISOBUTYLE
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 0.11 mg/L
- Assessment factor:
- 1 000
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 1.1 mg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0.011 mg/L
- Assessment factor:
- 10 000
- Extrapolation method:
- assessment factor
STP
- Hazard assessment conclusion:
- no hazard identified
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 0.66 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 0.066 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 0.069 mg/kg soil dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential for bioaccumulation
Additional information
Isobutyl-R-lactate has a low potential for adsorption to sediment and soil and is readily biodegradable. Acute aquatic toxicity test results for isobutyl-S-lactate were used in the risk assessment since chronic data were neither available for isobutyl-R-lactate nor for the optical antipode isobutyl-S-lactate. While aquatic toxicity against aquatic invertebrates and algae is covered by experimental results, the short-term toxicity of isobutyl-R-lactate against fish was estimated by validated QSAR models. One of these calculations revealed the lowest effect value across all trophic levels (96 -h LC50 of 108 mg/L) and was therefore selected for PNEC derivation. In an activated sludge respiration inhibition study an EC50 of >1000 mg/L was determined. Therefore, isobutyl-R-lactate is not considered to elicit any adverse effects against STP organisms that would identify a relevant hazard and may justify PNEC derivation for regulatory purposes.
Conclusion on classification
Isobutyl-R-lactate has a low potential for adsorption to sediment and soil and is readily biodegradable. In aquatic toxicity tests, the test item did not reveal any LC50/EC50 values below 100 mg/L, and would thus not be classified as hazardous to the aquatic environment in accordance with Section 4.1.2.6., Annex I of Regulation 1272/2008/EC.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
