Benzyl phenylacetate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1971

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1971

Report date:

1971

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

no

Remarks:

test performed prior to the GLP guidance

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Benzyl phenylacetate

EC Number:

203-008-4

EC Name:

Benzyl phenylacetate

Cas Number:

102-16-9

Molecular formula:

C15H14O2

IUPAC Name:

benzyl phenylacetate

Specific details on test material used for the study:

TEST SUBSTANCE
Name (as stated in the report): Labeled 71-39 Benzyl Phenyl Acetate
Aspect : Clear liquid

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Details on test animals or test system and environmental conditions:

Not specified

Administration / exposure

Route of administration:

oral: unspecified

Vehicle:

not specified

Doses:

5000ml/kg

No. of animals per sex per dose:

Main study:
5 males and 5 females
Each animal received a 1 dose of 5000 ml/Kg

Control animals:

no

Details on study design:

The animals were observed for 14 days.

Results and discussion

Preliminary study:

Dose 5000 mg/Kg -> No death on 2 animals tested
Dose 1260 mg/Kg -> No death on 2 animals tested
Dose 316 mg/Kg -> No death on 2 animals tested

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 5 000 mg/kg bw

Based on:

test mat.

Mortality:

2 deaths on days 2

Any other information on results incl. tables

All rats showed sedation for 24 hours after dosing.

Autopsy revealed no unsual findings

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

The LD50 of BENZYL PHENYL ACETATE in rat is likely to be in excess of 5.0 ml/Kg bw. Hence the GHS criteria are not met for classification.

Executive summary:

The substance RIFM 71 -39 BENZYL PHENYL ACETATE was found to have an LD50 in rat greater than 5.000 mg/Kg bw. Hence the GHS criteria are not met for the acute oral classification classification.