Registration Dossier

Administrative data

Endpoint:
sub-chronic toxicity: inhalation
Data waiving:
exposure considerations
Justification for data waiving:
other:
Justification for type of information:
JUSTIFICATION FOR DATA WAIVING

exposure considerations
Likelihood of exposures via inhalation is low considering that di-C16-C18 (evennumbered) alkyl tripropylenetetramine is a viscous fluid with a high boiling point (> 400 °C) and very low vapour pressure (1.3 x 10-6 Pa at 20°C). Its use is limited to industrial and professional users and does not involve the forming of aerosols, particles or droplets of an inhalable size. So, exposure to humans via the inhalation route will be unlikely to occur. Furthermore, the substance is classified as severe irritant, whereas repeated dose studies by oral route indicated low systemic toxicity. This means that effects by inhalation will rather be characterised by local irritation than systemic toxicity.

Data source

Materials and methods

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion