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EC number: 941-593-4
CAS number: 1623405-26-4
The safety assessment according to Annex 1 does not indicate the need to investigate further the effects on aquatic organisms. Therefore no chronic fish testing is required.
The safety assessment
according to Annex 1 does not indicate the need to investigate further
the effects on aquatic organisms. Therefore no chronic fish testing is
required. In addition, fish are in general less sensitive to cationic
surfactants as observed for linear alkyl diamines or quats compared to
algae and daphnia. The available acute fish data for the diamines
category which covers an alkyl chain length range from C12 to C18 reveal
a comparable toxicity, independent of this alkyl chain length.
For the calculation of
the PNECaquatic it is considered unlikely that fish toxicity will be
critical for tetramine di-C16 -18. Hence any additional long-term
toxicity testing with fish will not add scientific value to the
ecotoxicity profile of this substance other than for obtaining a lower
assessment factor. It is therefore concluded that for scientific reasons
and in accordance to REACH legislation further testing on fish has to be
avoided for reasons of animal welfare and that based on the weight of
evidence available and the ecotoxicity data for several cationic
surfactants a safety factor of 50 will be applied for the derivation of
The waiving of the
long-term fish test is supported by the low acute to chronic ratio
observed in the long-term daphnia test. A low acute-to-chronic ratio is
indicative of a non-specific mode of action and is often associated with
not systemic effects. This observation is consistent with the known
effects of cationic surfactants on aquatic organisms, where toxicity is
associated with physical binding to respiratory membranes. This explains
the steep concentration curves seen and the lack of intermediate chronic
effects on reproduction.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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