Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 310-217-5 | CAS number: 132940-73-9 Extractives and their fisically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Melaleuca viridiflora, Myrtaceae.
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2002
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only short abstract available
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- Gas Chromatography: An Investigative Tool in Multiple Allergies to Essential Oils.
- Author:
- Dharmagunawardena B, Takwale A, Sanders KJ, Cannan S, Rodger A and Ilchyshyn A
- Year:
- 2 002
- Bibliographic source:
- Contact Dermatitis. 47(5): 288-292
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- case report
- Principles of method if other than guideline:
- Method: Single Patch test performed in a patient
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Melaleuca viridiflora extract
- EC Number:
- 310-217-5
- EC Name:
- Melaleuca viridiflora extract
- Cas Number:
- 132940-73-9
- IUPAC Name:
- Essential oil of Melaleuca viridiflora (Myrtaceae) obtained from twigs and leaves by steam distillation
- Test material form:
- other: oil
- Details on test material:
- - Name of test material (as cited in study report): Niaouli oil
Constituent 1
Method
- Type of population:
- other: clinical case presented with suspected allergic contact dermatitis
- Controls:
- No
- Route of administration:
- dermal
Results and discussion
- Results of examinations:
- - Niaouli oil showed a positive reaction (oedematous/vesicular reaction) on Day 4.
- It was found to be composed of α-pinene (>1 %), terpineol (>10 %) and caryophylene (>10 %).
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Conclusions:
- Niaouli oil showed a positive reaction (oedematous/vesicular reaction) on Day 4. It was found to be composed of α-pinene (>1 %), terpineol (>10 %) and caryophylene (>10 %).
- Executive summary:
In a skin sensitisation study, a female patient (51 year old professional aromatherapist presented with suspected allergic contact dermatitis) was applied with occlusive patches containing niaouli oil diluted in white petrolatum, for 48 h. The reactions were observed at 30 min. after removal of patches and on Day 4. The composition of the oil was analysed using GC-MS chromatography.
Niaouli oil showed a positive reaction (oedematous/vesicular reaction) on Day 4. It was found to be composed of α-pinene (>1 %), terpineol (>10 %) and caryophylene (>10 %).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
