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Description of key information

In vitro bioavailability studies in artificial body fluids were conducted with the target substance titanium nitride.

Key value for chemical safety assessment

Bioaccumulation potential:
low bioaccumulation potential

Additional information

The bioaccessibility of titanium nitride as a surrogate for bioavailability was measured. For this purpose the solubility of titanium nitride was determined in artificial body fluid (gastric fluid, interstitial fluid, lysosomal fluid and artificial perspiration) using the EPA method #200.8 (ICP/MS). Results were reported as µg titanium/g sample and % titanium release/titanium content.

The bioavailability ranged from below the detection limit % (2 hours, artificial perspiration) to 2.34 % (24 hours, simulated gastric fluid). Based on the results, the bioavailability of titanium nitride would be expected to be low to very low for all routes of administration and best at strong acidic pH.