Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 247-117-5 | CAS number: 25583-20-4
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
No substance specific data on repeated dose toxicity is available for titanium nitride. Due to similar physico-chemical properties, similar transformation/dissolution results and similar in vitro bioaccessibility in synthetic body fluids compared to titanium dioxide, data from TiO2 can be used for read-across.
Available data from a chronic (2-year) oral repeated dose toxicity study with TiO2 in rats showed that the substance had no appreciable effect on body weights of rats of either sex. Other than white feces, there were no treatment-related clinical signs and no adverse effects up to 50,000 ppm in feed, corresponding to 3,500 mg/kg bw/day, which is above the recommended limit dose for a chronic study of 1,000 mg/kg bw/day. Survival of the rats at the end of the bioassay was not affected by the test chemical (IUCLID Section 7.5.1).
In addition, a bioelution test with titanium nitride showed no bioaccessibility in interstitial fluid and very low bioaccessibility (0.11%) under the very harsh conditions of lysosomal fluid. Therefore, no hazard is expected after inhalation exposure to titanium nitride.
In addition, no to very low (0.01%) titanium release after 2 to 24 hours in artificial perspiration fluid and very low bioaccessibility of titanium in simulated gastric fluid after 2 hours (0.34%) to 24 hours (2.34%), respectively, after up to 24 hours (IUCLID Section 7.1.1). Therefore, no hazard is expected after oral and dermal exposure to titanium nitride.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
No substance specific data on repeated dose toxicity is available for titanium nitride. Due to similar physico-chemical properties, similar transformation/dissolution results and similar in vitro bioaccessibility in synthetic body fluids compared to titanium dioxide, data from TiO2 can be used for read-across.
Available data from a chronic (2-year) oral repeated dose toxicity study with TiO2 in rats showed that the substance had no appreciable effect on body weights of rats of either sex. Other than white feces, there were no treatment-related clinical signs and no adverse effects up to 50,000 ppm in feed, corresponding to 3,500 mg/kg bw/day, which is above the recommended limit dose for a chronic study of 1,000 mg/kg bw/day. Survival of the rats at the end of the bioassay was not affected by the test chemical (IUCLID Section 7.5.1).
In addition, a bioelution test with titanium nitride showed no bioaccessibility in interstitial fluid and very low bioaccessibility (0.11%) under the very harsh conditions of lysosomal fluid. Therefore, no hazard is expected after inhalation exposure to titanium nitride.
In addition, no to very low (0.01%) titanium release after 2 to 24 hours in artificial perspiration fluid and no hazard is expected after dermal exposure to titanium nitride. Low bioaccessibility of titanium was observed in simulated gastric fluid after 2 hours (0.34%) to 24 hours (2.34%), respectively (IUCLID Section 7.1.1).
Therefore, the oral NOAEL of 3,500 mg of titanium dioxide/kg bw/d for chronic toxicity in rats is used as dose descriptor for the calculation of a DNEL for systemic effects for humans exposed orally to comparable titanium compounds, like titanium dioxide.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
