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Physical & Chemical properties

Nanomaterial agglomeration / aggregation

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Administrative data

Endpoint:
nanomaterial agglomeration/aggregation
Remarks:
SEM
Type of information:
experimental study
Adequacy of study:
key study
Study period:
25/04/2018-11/06/2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report date:
2018

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions - Method A: Particle Size Distribution (effective hydrodynamic radius)
GLP compliance:
no
Remarks:
but study conducted in a laboratory holding a current statement of GLP compliance.
Type of method:
scanning electron microscopy
Details on methods and data evaluation:
For the examination of the dry solid, the test substance, titanium nitride, was prepared by direct transfer of the dry powder onto adhesive conducting tape, mounted onto a SEM specimen holder.

For the examination of the dispersed solid, approximately 3 mg of the test substance, titanium nitride, was weighed out and added to 5 mL of methanol and gently shaken. An aliquot of approximately 100 µL of the dispersed solution was then taken and added to a further 5 mL of methanol and gently shaken. This solution was then filtered through a system and onto filter paper, which was then coated in platinum, and analysed using the SEM.

The test substance was analysed between 5 kV to 15 kV using secondary electron imaging under high resolution mode, with a working distance of ~5 mm.

Radius Image Analysis Software was used to manually measure the particles observed

Test material

Constituent 1
Chemical structure
Reference substance name:
Titanium nitride
EC Number:
247-117-5
EC Name:
Titanium nitride
Cas Number:
25583-20-4
Molecular formula:
NTi
IUPAC Name:
titanium nitride
Test material form:
solid: nanoform

Data gathering

Instruments:
Hitachi S4700 Field Emission Scanning Electron Microscope, LIMS 2005, SOP 042.12/6

Results and discussion

Agglomerate / aggregate diameteropen allclose all
Key result
Mean diameter:
ca. 38.67 nm
Medium:
Dry powder (SEM)
Key result
Mean diameter:
ca. 43.35 nm
Medium:
dispersed (SEM)

Any other information on results incl. tables

SEM examination showed that the primary particles preferentiality formed into large aggregates, some as large as 25 μm. However, primary particles could also be observed.

Applicant's summary and conclusion

Conclusions:
The mean diameter of TiN in an OECD 110 study, measured by SEM, was 38.67 nm for the dry particles, and 43.35 nm for the dispersed particles.

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