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EC number: 247-117-5 | CAS number: 25583-20-4
Nanomaterial agglomeration / aggregation
Administrative data
- Endpoint:
- nanomaterial agglomeration/aggregation
- Remarks:
- SEM
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 25/04/2018-11/06/2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions - Method A: Particle Size Distribution (effective hydrodynamic radius)
- GLP compliance:
- no
- Remarks:
- but study conducted in a laboratory holding a current statement of GLP compliance.
- Type of method:
- scanning electron microscopy
- Details on methods and data evaluation:
- For the examination of the dry solid, the test substance, titanium nitride, was prepared by direct transfer of the dry powder onto adhesive conducting tape, mounted onto a SEM specimen holder.
For the examination of the dispersed solid, approximately 3 mg of the test substance, titanium nitride, was weighed out and added to 5 mL of methanol and gently shaken. An aliquot of approximately 100 µL of the dispersed solution was then taken and added to a further 5 mL of methanol and gently shaken. This solution was then filtered through a system and onto filter paper, which was then coated in platinum, and analysed using the SEM.
The test substance was analysed between 5 kV to 15 kV using secondary electron imaging under high resolution mode, with a working distance of ~5 mm.
Radius Image Analysis Software was used to manually measure the particles observed
Test material
- Reference substance name:
- Titanium nitride
- EC Number:
- 247-117-5
- EC Name:
- Titanium nitride
- Cas Number:
- 25583-20-4
- Molecular formula:
- NTi
- IUPAC Name:
- titanium nitride
- Test material form:
- solid: nanoform
Constituent 1
Data gathering
- Instruments:
- Hitachi S4700 Field Emission Scanning Electron Microscope, LIMS 2005, SOP 042.12/6
Results and discussion
Agglomerate / aggregate diameteropen allclose all
- Key result
- Mean diameter:
- ca. 38.67 nm
- Medium:
- Dry powder (SEM)
- Key result
- Mean diameter:
- ca. 43.35 nm
- Medium:
- dispersed (SEM)
Any other information on results incl. tables
SEM examination showed that the primary particles preferentiality formed into large aggregates, some as large as 25 μm. However, primary particles could also be observed.
Applicant's summary and conclusion
- Conclusions:
- The mean diameter of TiN in an OECD 110 study, measured by SEM, was 38.67 nm for the dry particles, and 43.35 nm for the dispersed particles.
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