Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 276-763-0 | CAS number: 72676-55-2
Endpoint summary
Administrative data
Description of key information
Additional information
Stability
Hydrolysis
Key Study:
In an OECD 111 study, conducted according to GLP, transformation of 5,5'-Dithiodi-1,3,4-thiadiazole-2(3H)-thione was observed at environmental relevant pHs (pH 4, 7 and 9), however, transformation was not considered to originate from true hydrolysis,i.e.chemical breakdown due to reaction with water. Significant, extremely rapid transformation occurred prior to analysis.5,5'-Dithiodi-1,3,4-thiadiazole-2(3H)-thione is expected to undergo non-hydrolytic transformations (Envigo Research Limited, 2016).
Two reaction pathways must be considered in any experiments involving 5,5'-Dithiodi-1,3,4-thiadiazole-2(3H)-thione:
• Tautomerization; and
• Disulfide exchange.
Tautomerization should rapidly produce an equilibrium mixture of thione and thiol forms of the test substance upon exposure to a protic solvent (such as water). The position of the equilibrium will depend on temperature, solvent, and pH of the solution.
Disulfide exchange, involving the cleavage and reformation of the disulfide bridge, may be slower and the rate will depend on exposure to heat, light, and reducing or oxidizing species. Both the dimer and monomer present during this dynamic exchange will undergo tautomerization.
Biodegradation
Biodegradation in water: Screening
Key Study:
In an OECD Guideline 301B study, conducted according to GLP, 5,5'-Dithiodi-1,3,4-thiadiazole-2(3H)-thione achieved 0% biodegradation after 28 days and is considered not readily biodegradable (Envigo Research Limited, 2016).
Bioaccumulation
n-octanol Partition coefficient
Key study :
The partition coefficient (log10 Pow) of the test item is estimated based on the ratio of n-octanol solubility and water solubility to be 1.46 at 25.0 +/- 1°C.
Transport and distribution
Adsorption / desorption
Key Study:
Using KOCWIN, version 2.00, September 2010 (©2000 to 2008, U.S. EPA), and taking into account the predominant anionic forms expected to be present within the environmentally relevant pH range (pH 5.5 to 7.5), the estimated adsorption coefficient (log Koc) values for 5,5'-Dithiodi-1,3,4-thiadiazole-2(3H)-thione ranges from -4.55 to 1.97. 5,5'-Dithiodi-1,3,4-thiadiazole-2(3H)-thione is expected to display high to very high mobility in soils (Harlan Laboratories Ltd, 2016).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
