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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

Currently viewing:

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
other: Authoritative data base
Title:
Determination of LD50 value (Dermal) of chemical 2,5-Dichloronitrobenzene
Author:
IFA (GESTIS)
Year:
2016
Bibliographic source:
GESTIS - Substance Database (Information system on hazardous substances of the Berufsgenossenschaften)

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as below
Principles of method if other than guideline:
Acute dermal toxicity of chemical 2,5-Dichloronitrobenzene was determined in rats
GLP compliance:
not specified
Test type:
other: no data

Test material

Constituent 1
Chemical structure
Reference substance name:
1,4-dichloro-2-nitrobenzene
EC Number:
201-923-3
EC Name:
1,4-dichloro-2-nitrobenzene
Cas Number:
89-61-2
Molecular formula:
C6H3Cl2NO2
IUPAC Name:
1,4-dichloro-2-nitrobenzene
Constituent 2
Reference substance name:
2,5-Dichloronitrobenzene
IUPAC Name:
2,5-Dichloronitrobenzene
Details on test material:
- Name of test material (as cited in study report): 2,5-Dichloronitrobenzene
- Molecular formula (if other than submission substance): C6-H3-Cl2-N-O2
- Molecular weight (if other than submission substance): 192.001
- Substance type: Organic
- Physical state: Liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Duration of exposure:
no data
Doses:
2000 mg/kg bw
No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Interpretation of results:
other: not classified
Conclusions:
The LD50 value was found to be >2000 mg/kg in rats exposed to chemical 2,5-Dichloronitrobenzene in acute dermal test.
Executive summary:

Acute dermal toxiciyt test was performed to evaluate lethality of chemical 2,5-Dichloronitrobenzene.The animals were exposed by dermal route with dose concentration of 2000 mg/kg.

The animal only showed only a decrease of their spontaneous activity.2000 mg/kg did not lead to any deaths for rats.

The LD50 value was found to be >2000 mg/kg in rats exposed to chemical 2,5-Dichloronitrobenzene in acute dermal test.