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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data from handbook or collection of data

Data source

Reference
Reference Type:
other: Authoritative database
Title:
determination of eye irritation for CAS no: 124-63-0
Author:
HSDB
Year:
2018
Bibliographic source:
U.S. National Library of Medicine National Institutes of Health, Health & Human Services; 2018

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
An eye irritation study was conducted on rabbits for chemical Methanesulphonyl chloride (CAS no: 124-63-0) to assess its ocular irritation potential.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Methanesulphonyl chloride
EC Number:
204-706-1
EC Name:
Methanesulphonyl chloride
Cas Number:
124-63-0
Molecular formula:
CH3ClO2S
IUPAC Name:
Methanesulphonyl chloride
Test material form:
liquid
Specific details on test material used for the study:
- Name of test material (as cited in study report): Mesyl chloride (MSC)
- Molecular formula: CH3ClO2S
- Molecular weight: 110.1324 g/mol
- Substance type: Organic
- Physical state: liquid
- InChI: 1S/C2H6O3S/c1-5-6(2,3)4/h1-2H3
- Smiles: COS(=O)(=O)C

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
No data available

Test system

Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
Single application
Duration of treatment / exposure:
20 to 30 sec after instillation
Observation period (in vivo):
No data available
Duration of post- treatment incubation (in vitro):
No data available
Number of animals or in vitro replicates:
No data available
Details on study design:
No data available

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
24 h
Reversibility:
not specified
Remarks on result:
positive indication of irritation
Irritant / corrosive response data:
Instillation of test chemical reduced the response, but corneal opacity and congestion of the iris with no pupillary light reaction were still noted.

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritating to eyes) based on GHS criteria
Conclusions:
The chemical Methanesulphonyl chloride (CAS no: 124-63-0) was considered as severely irritating to the eyes of rabbits.
Executive summary:

An irritation study was conducted on rabbits for chemical Methanesulphonyl chloride (CAS no: 124-63-0) to assess its ocular irritation potential.

 

The rabbits were treated with single application of Methanesulphonyl chloride which caused irrigation of the eye 20 to 30 sec after instillation reduced the response, but corneal opacity and congestion of the iris with no pupillary light reaction were still noted.

 

Hence the chemical Methanesulphonyl chloride (CAS no: 124-63-0)was considered as severely irritating to the eyesof rabbits.

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