Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 220-780-8 | CAS number: 2897-60-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 5 June to 3 July 2008
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- [3-(2,3-epoxypropoxy)propyl]diethoxymethylsilane
- EC Number:
- 220-780-8
- EC Name:
- [3-(2,3-epoxypropoxy)propyl]diethoxymethylsilane
- Cas Number:
- 2897-60-1
- Molecular formula:
- C11H24O4Si
- IUPAC Name:
- diethoxy(methyl){3-[(oxiran-2-yl)methoxy]propyl}silane
- Reference substance name:
- [3-(2,3-epoxypropoxy)propyl]diethoxy(methyl)silane
- IUPAC Name:
- [3-(2,3-epoxypropoxy)propyl]diethoxy(methyl)silane
- Test material form:
- other: liquid
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- other: Crl:CD (SD) IGS BR VAF/Plus
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories Inc., USA
- Age at study initiation: 8 weeks
- Weight at study initiation: 154.4 to 181.2g
- Fasting period before study: yes
- Housing: individually in wire mesh cages
- Diet (ad libitum): LabDiet 5002, PMI
- Water (ad libitum): municipal water
- Acclimation period: 6 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19.81 to 22.09
- Humidity (%): 40 to 66
- Air changes (per hr): 14.5
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 17 June 2008 To: 3 July 2008
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: not stated
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: not stated - Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 6 female
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: twice daily
- Frequency of weighing: day of dosing, weekly thereafter including the day of necropsy
- Necropsy of survivors performed: yes - Statistics:
- Body weight was reported as groups means and standard deviations, computed by Provantis v6.5
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- None
- Clinical signs:
- other: None
- Gross pathology:
- No findings
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Administration of methyl(glycidoxypropyl) diethoxysilane to female rats at 2000 mg/kg bw did not result in any remarkable findings and the LD50 was considered to be greater than 2000 mg/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
