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The test substance is susceptible to two separate hydrolysis reactions of its different functional groups, as described in Section 5.1.2 of IUCLID. The available aquatic ecotoxicity studies conducted with this substance are consistent with this and also indicate the formation of precipitated condensation products at longer time scales. Therefore it is likely that the test organisms were predominantly exposed to a mixture of the hydrolysis products of the substance, with some exposure to the parent substance at the beginning of the tests.

 

Short-term toxicity tests results are available for freshwater fish (Oncorhynchus mykiss), invertebrates (Daphnia magna) and algae (Scenedesmus subspicatus) for [3-(2,3-epoxypropoxy)propyl]diethoxy(methyl)silane (CAS 2897-60-1). The relevant short-term values are:

Fish: LC50 (96 h): 139 mg/l (expressed in terms of [3-(2,3-epoxypropoxy)propyl]methylsilanediol). Although test concentrations were analytically verified for parent substance, the key value is reported in terms of nominal concentration because the organisms were exposed to a mixture of parent substance and hydrolytical degradation products.

Daphnia: EC50 (48 h): 15.5 mg/l (expressed in terms of [3-(2,3-epoxypropoxy)propyl]methylsilanediol). Although test concentrations were analytically verified for parent substance, the key value is reported in terms of nominal concentration because the organisms were exposed to a mixture of parent substance and hydrolytical degradation products.

Algae: ErC50 (72 h): >25 mg/l (expressed in terms of [3-(2,3-epoxypropoxy)propyl]methylsilanediol). Although test concentrations were analytically verified for parent substance, the key value is reported in terms of nominal concentration because the organisms were exposed to a mixture of parent substance and hydrolytical degradation products.

 

There are no reliable microorganism toxicity data available for [3-(2,3-epoxypropoxy)propyl]diethoxy(methyl)silane (CAS 2897-60-1), therefore good quality data for the structurally-related substance, [3-(2,3-epoxypropoxy)propyl]triethoxysilane (CAS 2602-34-8), have been read across. An activated sludge respiration inhibition 3 hour EC50 value of >1000 and NOEC of 1000 mg/l (nominal) was determined in a reliable study.

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