Registration Dossier
Registration Dossier
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EC number: 205-759-3 | CAS number: 150-39-0
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study meets generally accepted scientific principles For read-across justification refer to section 13.
Data source
Reference
- Reference Type:
- publication
- Title:
- The Metabolism of 14C Labeled Ethylenediaminetetraacetic Acid in Human Beings
- Author:
- Foreman H et al.
- Year:
- 1 954
- Bibliographic source:
- J Lab Clin Med 43, 566-571
Materials and methods
- Principles of method if other than guideline:
- Details on study design: - 3 young healthy adult male were used in each application group
Endpoint addressed: basic toxicokinetics
Endpoint addressed: dermal absorption
Test material
- Reference substance name:
- Sodium calcium edetate
- EC Number:
- 200-529-9
- EC Name:
- Sodium calcium edetate
- Cas Number:
- 62-33-9
- Molecular formula:
- C10H12CaN2O8.2Na
- IUPAC Name:
- calcium disodium 2,2',2'',2'''-(ethane-1,2-diyldinitrilo)tetraacetate
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- CaNa2EDTA does not penetrate the skin.
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