Registration Dossier

Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
1974
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Very limited reported study, in this study an 80% solution was tested.
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975
Report Date:
1975

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Skin irritation was evaluated following application of a 80% aqueous solution
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid - liquid: suspension
Details on test material:
Name: Cutrilon (copper complex of Trilon B)
Appearance: solid

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals and environmental conditions:
No details available.

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
water
Controls:
not specified
Amount / concentration applied:
No info
Duration of treatment / exposure:
The backs of the animals were treated for 1, 5, 15 min or20 h.
The ears of the animals were treated for 20 h.
Observation period:
8 days
Number of animals:
not indicated

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Remarks on result:
other: see below
Irritant / corrosive response data:
Effects on the back after 24 h: no abnormalities observed following exposure for 1, 5 or 15 min. Slight red staining observed following 20 h of exposure.
Effects on the back after 8 days: no abnormalities observed.

Effects on the ear after 24 h: slight redness observed following exposure for 20 h
Effects on the ear after 8 days: no abnormalities observed

Applicant's summary and conclusion

Interpretation of results:
slightly irritating
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
Although slight irritation (redness) was observed, no classification and labeling was considered to be needed based on the results of this study.