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EC number: 210-441-2 | CAS number: 615-66-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- The supporting QMRF report has been attached
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The prediction is done using QSAR Toolbox version 3.3
- GLP compliance:
- not specified
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- Daphnia magna
- Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 48 h
- Test temperature:
- 22 degC
- Reference substance (positive control):
- not specified
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 142.21 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- test mat.
- Basis for effect:
- other: Intoxication
- Validity criteria fulfilled:
- not specified
- Conclusions:
- A study was predicted using OECD QSAR toolbox version 3.3 (2017); to assess the toxicity effect of 2-chloro-p-phenylenediamine in aquatic invertebrate (Daphnia magna) in a 48 hours of exposure. The median effective concentration (EC50) for the test substance, 2-chloro-p-phenylene diamine, in daphnia magna on a intoxication effect was estimated to be 142.21 mg/L.
- Executive summary:
A study was predicted using OECD QSAR toolbox version 3.3 (2017); to assess the toxicity effect of 2-chloro-p-phenylenediamine in aquatic invertebrate (Daphnia magna) in a 48 hours of exposure. The median effective concentration (EC50) for the test substance, 2-chloro-p-phenylenediamine, in daphnia magna on a intoxication effect was estimated to be 142.21 mg/L. Thus, on the basis of this EC50 value and according to CLP Criteria for aquatic classification of the substance, it is concluded that 2-chloro-p-phenylenediamine (CAS No. 615 -66 -7) does not exhibit toxicity to aquatic invertebrate (daphnia magna).
Reference
The
prediction was based on dataset comprised from the following
descriptors: EC50
Estimation method: Takes average value from the 6 nearest neighbours
Domain logical expression:Result: In Domain
(((((((((((("a"
or "b" or "c" or "d" or "e" )
and ("f"
and (
not "g")
)
)
and "h" )
and ("i"
and (
not "j")
)
)
and "k" )
and "l" )
and ("m"
and (
not "n")
)
)
and ("o"
and (
not "p")
)
)
and ("q"
and (
not "r")
)
)
and ("s"
and (
not "t")
)
)
and ("u"
and (
not "v")
)
)
and ("w"
and "x" )
)
Domain
logical expression index: "a"
Referential
boundary: The
target chemical should be classified as Anilines (Acute toxicity) by
US-EPA New Chemical Categories
Domain
logical expression index: "b"
Referential
boundary: The
target chemical should be classified as Radical AND Radical >> Radical
mechanism via ROS formation (indirect) AND Radical >> Radical mechanism
via ROS formation (indirect) >> Single-Ring Substituted Primary Aromatic
Amines AND SN1 AND SN1 >> Nucleophilic attack after metabolic nitrenium
ion formation AND SN1 >> Nucleophilic attack after metabolic nitrenium
ion formation >> Single-Ring Substituted Primary Aromatic Amines by DNA
binding by OASIS v.1.3
Domain
logical expression index: "c"
Referential
boundary: The
target chemical should be classified as SN1 AND SN1 >> Nitrenium Ion
formation AND SN1 >> Nitrenium Ion formation >> Primary aromatic amine
by DNA binding by OECD
Domain
logical expression index: "d"
Referential
boundary: The
target chemical should be classified as Weak binder, NH2 group by
Estrogen Receptor Binding
Domain
logical expression index: "e"
Referential
boundary: The
target chemical should be classified as Anilines (amino-para) AND
Anilines (Unhindered) by Aquatic toxicity classification by ECOSAR
Domain
logical expression index: "f"
Referential
boundary: The
target chemical should be classified as Not possible to classify
according to these rules by DPRA Lysine peptide depletion
Domain
logical expression index: "g"
Referential
boundary: The
target chemical should be classified as Low reactive OR Low reactive >>
Activated haloarenes OR Low reactive >> N-substituted aromatic amides by
DPRA Lysine peptide depletion
Domain
logical expression index: "h"
Referential
boundary: The
target chemical should be classified as High (Class III) by Toxic hazard
classification by Cramer (original) ONLY
Domain
logical expression index: "i"
Referential
boundary: The
target chemical should be classified as No Data by Ultimate biodeg
Domain
logical expression index: "j"
Referential
boundary: The
target chemical should be classified as > 100 days OR 10 to 100 days by
Ultimate biodeg
Domain
logical expression index: "k"
Referential
boundary: The
target chemical should be classified as Class 3 (unspecific reactivity)
by Acute aquatic toxicity classification by Verhaar (Modified) ONLY
Domain
logical expression index: "l"
Referential
boundary: The
target chemical should be classified as Reactive unspecified by Acute
aquatic toxicity MOA by OASIS ONLY
Domain
logical expression index: "m"
Referential
boundary: The
target chemical should be classified as Aromatic amine [-NH2 or
-NH-] AND Aromatic chloride [-CL] AND Aromatic-H by Biodegradation
fragments (BioWIN MITI)
Domain
logical expression index: "n"
Referential
boundary: The
target chemical should be classified as Not calculated OR Pyridine ring
by Biodegradation fragments (BioWIN MITI)
Domain
logical expression index: "o"
Referential
boundary: The
target chemical should be classified as Halogens AND Non-Metals by
Groups of elements
Domain
logical expression index: "p"
Referential
boundary: The
target chemical should be classified as Alkali Earth OR Metalloids by
Groups of elements
Domain
logical expression index: "q"
Referential
boundary: The
target chemical should be classified as Aminoaniline, para AND Aniline
AND Aryl AND Aryl halide AND Precursors quinoid compounds by Organic
Functional groups
Domain
logical expression index: "r"
Referential
boundary: The
target chemical should be classified as Amidine by Organic Functional
groups
Domain
logical expression index: "s"
Referential
boundary: The
target chemical should be classified as Aminoaniline, para AND Aniline
AND Aryl AND Aryl halide AND Precursors quinoid compounds by Organic
Functional groups
Domain
logical expression index: "t"
Referential
boundary: The
target chemical should be classified as Ether by Organic Functional
groups
Domain
logical expression index: "u"
Referential
boundary: The
target chemical should be classified as Aminoaniline, para AND Aniline
AND Aryl AND Aryl halide AND Precursors quinoid compounds by Organic
Functional groups
Domain
logical expression index: "v"
Referential
boundary: The
target chemical should be classified as Guanidine by Organic Functional
groups
Domain
logical expression index: "w"
Parametric
boundary:The
target chemical should have a value of log Kow which is >= -0.571
Domain
logical expression index: "x"
Parametric
boundary:The
target chemical should have a value of log Kow which is <= 0.841
Description of key information
A study was predicted using OECD QSAR toolbox version 3.3 (2017); to assess the toxicity effect of 2-chloro-p-phenylenediamine in aquatic invertebrate (Daph nia magna) in a 48 hours of exposure. The median effective concentration (EC50) for the test substance, 2-chloro-p-phenylenediamine, in daphnia magna on a intoxication effect was estimated to be 142.21 mg/L. Thus, on the basis of this EC50 value and according to CLP Criteria for aquatic classification of the subst ance, it is concluded that 2-chloro-p-phenylenediamine (CAS No. 615 -66 -7) does not exhibit toxicity to aquatic invertebrate (daphnia magna).
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 142.21 mg/L
Additional information
Various studies including predicted results from the validated model and experimental study from a peer-reviewed journal for toxicity to aquatic invertebrate with the target substance 2-chloro-p-phenylenediamine (CAS No. 615-66-7) and to its relevant read across substance aniline (CAS No. 62-53-3) by considering its structure-activity relationships, were summarized as follows:
A study was predicted using OECD QSAR toolbox version 3.3 (2017); to assess the toxicity effect of 2-chloro-p-phenylenediamine in aquatic invertebrate (Daphni a magna) in a 48 hours of exposure. The median effective concentration (EC50) for the test substance, 2-chloro-p-phenylenediamine, in daphnia magna on a intoxication effect was estimated to be 142.21 mg/L.
In addition, based on the Ecological Structure Activity Relationships (ECOSAR) Predictive Model version 1.11 (2016), the median lethal concentration (LC50) for the test substance, 2-chloro-p-phenylenediamine, in aquatic invertebrate (Daphnia magna) was estimated to be 2095.96 mg/L on the basis of mortality effect in a 48 hour study.
Moreover, this test was carried out by Slooff,W. ( Aquat. Toxicol.4:73-82,1983) on Gammarus pulex (Scud) with the substance aniline (CAS No.- 62-53-3) in a 48 hours of exposure. The lethal concentration to 50% of test organisms was determined. The median lethal concentration (LC50) for the test substance, aniline, in aquatic invertebrate Scenedesmus subspicatus was determined to be 112.0 mg/L on the basis of mortality effect in a 48 hours study.
Based on the above predicted and experimental studies for target substance 2-chloro-p-phenylenediamine (CAS No. 615-66-7) and to its read across substance aniline (CAS No. 62-53-3), the effective concentration EC50 value was found to be 142.21 mg/L and LC50 value was found to be in the range of 112.0 to 2095.96 mg/L. Thus, on the basis of this EC50 and LC50 value and according to CLP Criteria for aquatic classification of the substance, it is concluded that 2-chloro-p-phenylenediamine (CAS No. 615-66-7) does not exhibit toxicity to aquatic invertebrate.
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