Registration Dossier

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
Data is from Authorative database

Data source

Reference
Reference Type:
other: Authorative database
Title:
RTECS® Registry of Toxic Effects of Chemical Substances: 2,3Xylenol
Author:
RTECS
Year:
2016
Bibliographic source:
RTECS (Registry of Toxic Effects of Chemical Substances); Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 205, 1994

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as below
Principles of method if other than guideline:
The acute oral toxicity study of 2, 3-Dimethylphenol in rat
GLP compliance:
not specified
Test type:
other: No data
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2,3-xylenol
EC Number:
208-395-3
EC Name:
2,3-xylenol
Cas Number:
526-75-0
Molecular formula:
C8H10O
IUPAC Name:
2,3-xylenol
Details on test material:
- Name of test material (as cited in study report): 2,3-xylenol
- Molecular formula (if other than submission substance): C8H10O
- Molecular weight (if other than submission substance): 122.16 g/mole
- Substance type: Organic
- Physical state: Solid
- Purity: No data available
- Impurities (identity and concentrations): No data available
Specific details on test material used for the study:
- Name of test material (as cited in study report): 2,3-xylenol
- Molecular formula (if other than submission substance): C8H10O
- Molecular weight (if other than submission substance): 122.16 g/mol
- Substance type: Organic
- Physical state: Solid
- Purity: No data available
- Impurities (identity and concentrations): No data available

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data available

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No data available
Doses:
562 mg/kg bw
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
562 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 50 % mortality observed
Mortality:
No data available
Clinical signs:
No data available
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
LD50 was considered to be 562 mg/kg bw whe rats were treated with 2,3-dimethylphenol orally.
Executive summary:

In a acute oral toxicity study,  rat were treated with 2,3-dimethylphenol orally. 50 % mortality were observed in treated rat at 562 mg/kg bw. Therefore, LD50 was considered to be 562 mg/kg bw whe rats were treated with 2,3-dimethylphenol orally.