Registration Dossier
Registration Dossier
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EC number: 941-732-9 | CAS number: -
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
In a key, static 72 hour Pseudokirchneriella subcapitata growth inhibition test (OECD 201, KS=1), 10000 cells/mL were exposed to the Water Accommodated Fraction (WAF) of heavy cracked fuel oils (MRD-10-579) at nominal concentrations of 0.05, 0.23, 1.01, 4.56 and 20.5 mg/L. The 72 hour EL50 was 0.32 mg/L and NOELR was 0.05 mg/L based on growth rate (EMBSI 2012b).
In seven reliable supporting 72-hour algae (Pseudokirchnerella subcapitata) toxicity studies using WAF methodology, the EL50 values based on growth rate and biomass varied between 0.75 to >107 mg/L and 0 - <300mg/L, respectively (EMBSI, 2008j,k,l,m; Shell, 1997a, b).
Supporting PETROTOX (version 4.01) modelled values are available. PETROTOX computer model, which combines a partitioning model (used to calculate the aqueous concentration of hydrocarbon components as a function of substance loading) with the Target Lipid Model (used to calculate acute and chronic toxicity of non-polar narcotic chemicals). PETROTOX computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a petroleum substance and membrane-water partition coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism.
The model predicted an acute LL50 and chronic EL10 of the substance to microorganisms to be greater than 1,000 mg/L.
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