Registration Dossier
Registration Dossier
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EC number: 943-498-3 | CAS number: -
Toxicity to microorganisms
Administrative data
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study under GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Reaction mass of Methyl N-octadecylterephthalamate and N,N'-Dioctadecylterephthalamide
- IUPAC Name:
- Reaction mass of Methyl N-octadecylterephthalamate and N,N'-Dioctadecylterephthalamide
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test organisms
- Test organisms (species):
- activated sludge, domestic
- Details on inoculum:
- - Source of inoculum/activated sludge: non-adapted sludge from domestic STP Hildesheim
- Pretreatment: washed twice
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 3 h
Test conditions
- Test temperature:
- 20°C
- Nominal and measured concentrations:
- nominal: 100, 180, 320, 580, 1000 mg/l
- Reference substance (positive control):
- yes
- Remarks:
- Copper(II) sulfate pentahydrate
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Duration:
- 3 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Results with reference substance (positive control):
- EC50=105 mg/l
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- In the toxicity to microorganism study with a nominal loading of up to 1000 mg/L of the test item, no effects were observed.
- Executive summary:
In the toxicity test to microorganism, the effects of the test item with a nominal loading of 100, 180, 320, 580 and1000 mg/L, were determined according to OECD 209 guideline.
A non-adapted sludge from domestic STP was used and no analytical monitoring of the test item was carried out.
The effect levels based on the nominal loading of test item are LC50>1000mg/l, NOEC=1000mg/l.
The validity criteria of the test guideline were fulfilled.
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